Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

See all formats and pricing


Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

Evaluation of Two Modified Cardiac Troponin I Enzyme Immunoassays

Cornelia Haug / Max G. Bachem / Holger Woehrle / Martin Hetzel / Adolf Gruenert

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 40, Issue 8, Pages 837–839, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2002.145, June 2005

Publication History

Published Online:


One of the major challenges for manufacturers of troponin immunoassays is to optimize the low-end of the assays because diagnostic and therapeutic interventions are based on decreasing cutpoints. Recently published consensus documents of the European Society of Cardiology and the American College of Cardiology recommended the 99th percentile of a reference control group as cut-off for increased troponin I levels and suggested that imprecision at the 99th percentile for each assay should be ≤10%. In this study, we have evaluated two newly modified cardiac troponin I (cTnI) enzyme immunoassays (Dimension® cTnI assay, Dade Behring, Germany and AIA-PACK cTnI 2nd-Gen, Eurogenetics Tosoh, Belgium). With both assays all measured cTnI values in plasma and serum samples of apparently healthy volunteers were within the reference ranges given by the manufacturers. Intra-assay coefficients of variation of cTnI concentrations above the 99th percentile (given by the manufacturers) were below 17% and decreased with increasing cTnI concentrations. In most samples, the AIA-PACK cTnI assay yielded higher results; however, a close correlation between both assays was observed. Both tests exhibit acceptable overall performance, but (especially the Dimension ® cTnI assay) do not yet meet the above-mentioned precision in the low-end assay range. These data emphasize the need for cTnI assay standardization and for further optimization at clinical decision levels.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Sangita M. Patil, Mangesh P. Bankar, Ramchandra K. Padalkar, Abhijit P. Pathak, Shital S. Ghodke, Sonali S. Bhagat, and Rahul A. Ghone
Journal of Indian College of Cardiology, 2014, Volume 4, Number 1, Page 8
Hannsjörg Baum, Anika Hinze, Peter Bartels, and Dieter Neumeier
Clinical Biochemistry, 2004, Volume 37, Number 12, Page 1079
Eberhard Gurr and Knut Leitz
Clinical Chemistry and Laboratory Medicine, 2004, Volume 42, Number 9

Comments (0)

Please log in or register to comment.