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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 40, Issue 9


Coreceptor Usage and Biological Phenotypes of HIV-1 Isolates

Tonie Cilliers / Lynn Morris
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2002.160


The discovery of chemokine receptors as HIV-1 entry molecules or “coreceptors” has lead to a greater understanding of how HIV-1 infects human cells. This has provided insight into the biological properties of HIV-1 isolates and unravelled the meaning of the syncytium-inducing and non-syncytium-inducing phenotypes. Understanding how HIV-1 exploits these coreceptors has given way to novel approaches to controlling HIV. As a result a new class of drugs has emerged that are being tested to prevent virus infection and to act as an alternative, or adjunct, to existing anti-retroviral drugs for HIV-infected individuals.

About the article

Published Online: 2005-06-01

Published in Print: 2002-09-24

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 40, Issue 9, Pages 911–917, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2002.160.

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