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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

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1437-4331
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Volume 40, Issue 9 (Sep 2002)

Issues

Immunoglobulin G and Subclass Responses to Plasmodium falciparum Antigens: A Study in Highly Exposed Cameroonians

Vincent P. K. Titanji / Veronica D. Tamu / Theresia K. Nkuo Akenji / Anna S. Joutchop
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2002.164

Abstract

We conducted a cross-sectional study in Bolifamba village in the South West Province of Cameroon to determine antibody responses to crude Plasmodium falciparum antigens. A total of 347 subjects were examined. Parasite counts were obtained on thick blood films stained with Field's stain. Total immunoglobulin (Ig)G and IgG subclass levels were determined in serum samples from four groups comprising children 1 to 5 years old and adults ≥18 years with or without falciparum malaria parasites, using enzyme-linked immunosorbent assay with crude blood-stage antigens of Plasmodium falciparum strain F32 as target. Depending on the age group, malaria prevalence varied between 10% and 65% with a mean of 30.8%. Prevalence rate and parasite density declined with increasing age. Total IgG and IgG1-3 levels were significantly higher in adults than in children (p<0.05). Parasite-bearing individuals in both age groups had higher IgG titres than their non-infected counterparts, while subtype levels were not significantly different (p=0.05). These findings indicate that Bolifamba village could be a convenient site to study further the protective immunity to malaria.

About the article

Published Online: 2005-06-01

Published in Print: 2002-09-24


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2002.164.

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[1]
J. N. Dinga, S. D. Gamua, and V. P. K. Titanji
Parasite Immunology, 2017, Volume 39, Number 8, Page e12445
[2]
T. Nkuo Akenji, N. N. Ntonifor, H. K. Kimbi, E. L. Abongwa, J. K. Ching, M. B. Ndukum, D. N. Anong, A. Nkwescheu, M. Songmbe, M. G. Boyo, K. N. Ndamukong, and V. P. K. Titanji
Annals of Tropical Medicine & Parasitology, 2005, Volume 99, Number 3, Page 221
[3]
T.K. Nkuo Akenji, N.N. Ntonifor, J.K. Ching, H.K. Kimbi, K.N. Ndamukong, D.N. Anong, M.G. Boyo, and V.P.K. Titanji
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2005, Volume 99, Number 5, Page 325
[4]
Helen K Kimbi, Kevin K.A Tetteh, Spencer D Polley, and David J Conway
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2004, Volume 98, Number 5, Page 284
[5]
Vincent Pryde Kehdinga Titanji, Alfred Amambua-Ngwa, Damian Nota Anong, Stanley Kimbeng Mbandi, Emily Tangie, Ivo Tening, and Raymond Yengo
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 9

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