Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

See all formats and pricing
More options …
Volume 41, Issue 10 (Sep 2003)


Two MMP-2 Promoter Polymorphisms (–790T/G and –735C/T) in Chronic Heart Failure

Anna Vašků / Monika Goldbergová / Lydie Izakovičová Hollá / Lenka Špinarová / Jindřich Špinar / Jiří Vítovec / Jiří Vácha
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.197


Remodelling of extracellular matrix by activated matrix metalloproteinases is considered to contribute to progression of ventricle remodelling during chronic heart failure. The aim of this study was to associate two promoter polymorphisms, -790T/G and -735C/T, in the gene for matrix metalloproteinase (MMP)-2 (gelatinase A) with chronic heart failure (CHF). For this purpose, 164 patients (124 men, 40 women, median age 56 years, range 21-91 years) with CHF (functional class NYHA II-IV, ejection fraction median 25%, cardiothoracic index more than 50%) were compared with 196 control subjects without clinical signs of cardiovascular disease (131 men and 65 women, median age 56 years, range 27-84 years) in -790T/G and -735C/T MMP-2 genotype distributions and allelic frequencies. The genotypes were determined by polymerase chain reaction (PCR) with restriction analyses. A significant increase of the T allele of the -790T/G MMP-2 polymorphism (p = 0.04), as well as of the C allele of the -735C/T MMP-2 gene polymorphism, in patients with CHF was proven (p = 0.04). The heterozygote CT of the 735C/T MMP-2 polymorphism exhibits a 7 times higher odds ratio (OR) for the CHF patients with lower levels of total cholesterol (less than 5 mmol/l), especially for nonhypertensive CHF men (OR = 7.28, 95% confidence interval 1.51-35.03, p = 0.006). Determination of MMP polymorphisms in the regulatory area of the gene could help us to comprehend individual susceptibility of patients with CHF to MMP inhibitors based on known risks of MMP genotypes. Clin Chem Lab Med 2003; 41(10):12991303

About the article

Published Online: 2005-06-01

Published in Print: 2003-09-19

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.197.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Andrea R. Sabbatini, Natalia R. Barbaro, Ana Paula de Faria, Alessandra Mileni V. Ritter, Rodrigo Modolo, Nathália B. Correa, Veridiana Brunelli, Claudio Pinho, Vanessa Fontana, and Heitor Moreno
Gene, 2017, Volume 620, Page 23
Mengqi Guo, Guanlun Guo, and Xiaoping Ji
Journal of International Medical Research, 2016, Volume 44, Number 1, Page 15
Ana Rubia C. Beber, Evelise R. Polina, Andréia Biolo, Bruna L. Santos, Daiane C. Gomes, Vanessa L. La Porta, Virgílio Olsen, Nadine Clausell, Luis E. Rohde, Kátia G. Santos, and Gualtiero I. Colombo
PLOS ONE, 2016, Volume 11, Number 8, Page e0161666
HariOm Singh, Shruti D. Marathe, Vijay Nema, Manisha V. Ghate, and Raman R. Gangakhedkar
The Journal of Gene Medicine, 2016, Volume 18, Number 9, Page 250
Aldo Clerico, Simona Vittorini, Claudio Passino, and Michele Emdin
Critical Reviews in Clinical Laboratory Sciences, 2009, Volume 46, Number 3, Page 107
Virgilio Olsen, Luis E. Rohde, Luis Beck-da-Silva, Kátia G. Santos, Andréia Biolo, Nadine Clausell, and Michael Andrades
Canadian Journal of Cardiology, 2014, Volume 30, Number 3, Page 345
Fabiana Filigheddu
Molecular Diagnosis & Therapy, 2013, Volume 17, Number 4, Page 205
Priyanka Srivastava, Saumya Pandey, Balraj Mittal, and Rama D. Mittal
Indian Journal of Clinical Biochemistry, 2013, Volume 28, Number 1, Page 13
Priyanka Srivastava, Tasleem A. Lone, Rakesh Kapoor, and Rama Devi Mittal
Archives of Medical Research, 2012, Volume 43, Number 2, Page 117
Ali Gürkan, Gülnur Emingil, Buket Han Saygan, Gül Atilla, Serhat Çınarcık, Timur Köse, and Afig Berdeli
Archives of Oral Biology, 2008, Volume 53, Number 4, Page 337
Priyanka Srivastava, Rakesh Kapoor, and Rama D. Mittal
Urologic Oncology: Seminars and Original Investigations, 2013, Volume 31, Number 2, Page 247
Yihong Hua, Li Song, Naqiong Wu, Gaoqiang Xie, Xiangfeng Lu, Xiaohan Fan, Xianmin Meng, Dongfeng Gu, and Yuejin Yang
Clinica Chimica Acta, 2009, Volume 404, Number 2, Page 119
Merli Saare, Merit Lamp, Tanel Kaart, Helle Karro, Ülle Kadastik, Andres Metspalu, Maire Peters, and Andres Salumets
Fertility and Sterility, 2010, Volume 94, Number 4, Page 1560
Ebru Alp, Sevda Menevse, Murat Tulmac, Akin Yilmaz, Ridvan Yalcin, and Atiye Cengel
Genetic Testing and Molecular Biomarkers, 2011, Volume 15, Number 4, Page 193
Bangwei Cao, Hongli Yang, Howard Ding, Suxia Qi, Lei Gao, Hong Cui, Yue Dai, and Changqing Xu
Clinical Chemical Laboratory Medicine, 2007, Volume 45, Number 3
Ali Gürkan, Gülnur Emingil, Buket Han Saygan, Gül Atilla, Serhat Çınarcık, Timur Köse, and Afig Berdeli
Journal of Periodontology, 2007, Volume 78, Number 12, Page 2338
Yihong Hua, Naqiong Wu, Yuejin Yang, Xiangfeng Lu, Xianmin Meng, Li Song, and Dongfeng Gu
The American Journal of the Medical Sciences, 2009, Volume 337, Number 5, Page 344
Bego??a L??pez, Arantxa Gonz??lez, and Javier D??ez
Current Opinion in Nephrology and Hypertension, 2004, Volume 13, Number 2, Page 197

Comments (0)

Please log in or register to comment.
Log in