Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

See all formats and pricing
More options …
Volume 41, Issue 11


Comparison of the Influence of Volume-Oriented Training and High-Intensity Interval Training on Serum Homocysteine and Its Cofactors in Young, Healthy Swimmers

Markus Herrmann / John Wilkinson / Heike Schorr / Rima Obeid / Thomas Georg / Axel Urhausen / Jürgen Scharhag / Wilfried Kindermann / Wolfgang Herrmann
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.234


Background: Since homocysteine (Hcy) is a risk factor for cardiovascular and other diseases, it is important to know how exercise can modify it. Previous studies have suggested that endurance training influences Hcy. However, little is known about the effect of training intensity on Hcy. Materials and Methods: We investigated Hcy, vitamin B12, vitamin B6, folate and methylmalonic acid (MMA) before and after 3 weeks of volume-oriented training (VOL) (30 km/week) and high-intensity interval training (HIT) (20 km/week) in 20 young swimmers (16±2 years). Afterward, the athletes completed 5 days of recovery training. Results: The training induced a Hcy increase in HIT and VOL (6.47±0.95 μmol/l vs. 7.44±1.17 μmol/l and 7.33± 1.92 μmol/l vs. 8.28±1.42 μmol/l, respectively) that persisted during the recovery period (8.02±1.69 μmol/and 8.00±1.81 μmol/l, respectively). Vitamin B12 was unchanged after the training (539±166 ng/l vs. 556±192 ng/l and 480±144 ng/l vs. 491±124 ng/l, respectively) but decreased during the recovery period (459±134 ng/l and 451±116 ng/l, respectively). Folate showed an increase during the training (9.07±2.01 μg/vs. 11.71±4.08 μg/l and 10.34±2.32 μg/l vs. 11.13± 4.64 μg/l, respectively), which was reversible by the end of the recovery training (8.57±1.98 μg/l and 9.60±2.38 μg/l, respectively). Vitamin B6 and MMA did not change. For none of the measured parameters were there significant differences between HIT and VOL. Conclusion: Three weeks of strenuous swimming caused a prolonged Hcy increase, which was accompanied by changes in vitamin B12 and folate. The magnitude of these effects was not influenced by the training intensity.

About the article

Published Online: 2005-06-01

Published in Print: 2003-11-17

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 11, Pages 1525–1531, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.234.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Beatriz Maroto-Sánchez, Olga Lopez-Torres, Jara Valtueña, Pedro J. Benito, Gonzalo Palacios, Ángel Enrique Díaz-Martínez, Domingo González-Lamuño, Angelo Zinellu, Marcela González-Gross, and Ciriaco Carru
Amino Acids, 2018
Rafael Deminice, Diogo Farias Ribeiro, Fernando Tadeu Trevisan Frajacomo, and Shawn E Bearden
PLOS ONE, 2016, Volume 11, Number 3, Page e0151653
C.J.H.M. Klemann, J.E. Visser, L. Van Den Bosch, G.J.M. Martens, and G. Poelmans
Brain Pathology, 2017
Rachel Veasey, Crystal Haskell-Ramsay, David Kennedy, Karl Wishart, Silvia Maggini, Caspar Fuchs, and Emma Stevenson
Nutrients, 2015, Volume 7, Number 8, Page 6109
Sudhakar Veeranki and Suresh Tyagi
International Journal of Molecular Sciences, 2013, Volume 14, Number 7, Page 15074
Francesco Fazio, Giuseppe Piccione, Stefania Casella, Anna Assenza, Vanessa Messina, and Giovanni Caola
Journal of Equine Veterinary Science, 2010, Volume 30, Number 1, Page 39
Rafael Deminice, Helio Vannucchi, Lívia Maria Simões-Ambrosio, and Alceu Afonso Jordao
European Journal of Applied Physiology, 2011, Volume 111, Number 11, Page 2663
A.S. Rousseau, S. Robin, A.M. Roussel, V. Ducros, and I. Margaritis
Nutrition, Metabolism and Cardiovascular Diseases, 2005, Volume 15, Number 2, Page 125
Carla Manuela Crispim NASCIMENTO, Florindo STELLA, Célia Regina GARLIPP, Ruth Ferreira SANTOS, Sebastião GOBBI, and Lilian Teresa Bucken GOBBI
Psychogeriatrics, 2011, Volume 11, Number 2, Page 105
Medicine & Science in Sports & Exercise, 2009, Volume 41, Number 8, Page 1646
Nihal Gelecek, Nursen Teoman, Mehtap Ozdirenc, Lamia Pınar, Pınar Akan, Cem Bediz, and Omer Kozan
Annals of Nutrition and Metabolism, 2007, Volume 51, Number 1, Page 53
V. Gaume, F. Mougin, H. Figard, M.L. Simon-Rigaud, U.N. N’Guyen, J. Callier, J.P. Kantelip, and A. Berthelot
Annals of Nutrition and Metabolism, 2005, Volume 49, Number 2, Page 125

Comments (0)

Please log in or register to comment.
Log in