Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 41, Issue 12

Issues

The Application of Clinical Proteomics to Cancer and other Diseases

William Clarke / Zhen Zhang / Daniel W. Chan
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.239

Abstract

The term “clinical proteomics” refers to the application of available proteomics technologies to current areas of clinical investigation. The ability to simultaneously and comprehensively examine changes in large numbers of proteins in the context of disease or other changes in physiological conditions holds great promise as a tool to unlock the solutions to difficult clinical research questions. Proteomics is a rapidly growing field that combines high throughput analytical methodologies such as two-dimensional gel electrophoresis and SELDI mass spectrometry methods with complex bioinformatics to study systems biology–the system of interest is defined by the investigator. Even with all its potential, however, studies must be carefully designed in order to differentiate true clinical differences in protein expression from differences originating from variation in sample collection, variation in experimental condition, and normal biological variability. Proteomic analyses are already widely in use for clinical studies ranging from cancer to other diseases such as cardiovascular disease, organ transplant, and pharmacodynamic studies.

About the article

Published Online: 2005-06-01

Published in Print: 2003-12-04


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 12, Pages 1562–1570, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.239.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Cristina Núñez
Clinica Chimica Acta, 2019, Volume 490, Page 113
[2]
Ziad J. Sahab, Suzan M. Semaan, and Qing-Xiang Amy Sang
Biomarker Insights, 2007, Volume 2, Page 117727190700200
[3]
Rikke Leth-Larsen, Rikke R. Lund, and Henrik J. Ditzel
Molecular & Cellular Proteomics, 2010, Volume 9, Number 7, Page 1369
[4]
Amalia Vioque-Fernández, Eduardo Alves de Almeida, and Juan López-Barea
Biomarkers, 2009, Volume 14, Number 5, Page 299
[5]
Ran Wang, Shuai Huang, Jing Li, and Junseok Chae
Applied Physics Letters, 2014, Volume 105, Number 14, Page 143703
[6]
Yaşam Barlak, Orhan Değer, Meltem Çolak, Senem Karataylı, Abdurrahman Bozdayı, and Fulya Yücesan
Proteome Science, 2011, Volume 9, Number 1, Page 74
[7]
Christoph Röcken, Matthias P.A Ebert, and Albert Roessner
Pathology - Research and Practice, 2004, Volume 200, Number 2, Page 69
[8]
Svetlana Ignjatovic
Jugoslovenska medicinska biohemija, 2006, Volume 25, Number 2, Page 119
[10]
[11]
Mario Plebani
Clinica Chimica Acta, 2005, Volume 357, Number 2, Page 113
[12]
Therese Rosenling, Amos Attali, Theo M. Luider, and Rainer Bischoff
Clinica Chimica Acta, 2011, Volume 412, Number 11-12, Page 812
[13]
Ashima Sinha, Chetna Singh, Devendra Parmar, and Mahendra Pratap Singh
Life Sciences, 2007, Volume 80, Number 15, Page 1345
[14]
Emily I. Chen and John R. Yates
Molecular Oncology, 2007, Volume 1, Number 2, Page 144
[15]
Ann L. Miracle and Gerald T. Ankley
Reproductive Toxicology, 2005, Volume 19, Number 3, Page 321
[16]
Anu Kalia and R. P. Gupta
Critical Reviews in Biotechnology, 2005, Volume 25, Number 4, Page 173
[17]
Marie-Christine W. Gast, Carla H. van Gils, Lodewijk F.A. Wessels, Nathan Harris, Johannes M.G. Bonfrer, Emiel J.Th. Rutgers, Jan H.M. Schellens, and Jos H. Beijnen
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 6
[18]
Svetlana Ignjatovic
Jugoslovenska medicinska biohemija, 2006, Volume 25, Number 2, Page 119
[19]
Marie-Christine W. Gast, Jan H. M. Schellens, and Jos H. Beijnen
Breast Cancer Research and Treatment, 2009, Volume 116, Number 1, Page 17
[20]
Sergio Ciordia, Vivian de los Ríos, and Juan-Pablo Albar
Clinical and Translational Oncology, 2006, Volume 8, Number 8, Page 566
[21]
Tiphaine Monsinjon and Thomas Knigge
PROTEOMICS, 2007, Volume 7, Number 16, Page 2997
[22]
Jia-Xiang Wang, Jie-kai Yu, Li Wang, Qiu-Liang Liu, Jiao Zhang, and Shu Zheng
PROTEOMICS, 2006, Volume 6, Number 19, Page 5344
[23]
Gary L. Nelsestuen, Yan Zhang, Michael B. Martinez, Nigel S. Key, Bernd Jilma, Michael Verneris, Alan Sinaiko, and Raj S. Kasthuri
PROTEOMICS, 2005, Volume 5, Number 15, Page 4012
[24]
Jens Koopmann, Paul J. Thuluvath, Marianna L. Zahurak, Troels Z. Kristiansen, Akhilesh Pandey, Richard Schulick, Pedram Argani, Manuel Hidalgo, Stefano Iacobelli, Michael Goggins, and Anirban Maitra
Cancer, 2004, Volume 101, Number 7, Page 1609

Comments (0)

Please log in or register to comment.
Log in