Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 41, Issue 12


Therapeutic Drug Monitoring of 13 Antidepressant and Five Neuroleptic Drugs in Serum with Liquid Chromatography-Electrospray Ionization Mass Spectrometry

Ursula Gutteck / Katharina M. Rentsch
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.240


Therapeutic drug monitoring of antipsychotic drugs has become more and more important in recent years, and a well-organized therapeutic drug monitoring service with fast turn-around times is very important. Therefore, an analytical method coupling high-performance liquid chromatography to mass spectrometry with electrospray ionization in the positive mode was established in our laboratory.

Amitriptyline, citalopram, clomipramine (including norclomipramine), desipramine, dibenzepin, doxepin (including nordoxepin), escitalopram, flupentixol, fluphenazine, fluvoxamine, imipramine, nortriptyline, opipramol, pipamperone, reboxetine, thioridazine, trimipramine and zuclopenthixol were separated on a reversed-phase C18 column. The mobile phase consisted of acetonitrile and ammonium acetate buffer pH 4. Because of different organic solvents used for the liquid-liquid extraction and the different volumes of mobile phases in which the residues were dissolved, four analytical systems had to be applied.

Within the run-time of maximal 10 minutes the 13 antidepressant and five neuroleptic drugs were baseline separated on the corresponding mass-to-charge track. The calibration range of each drug was linear, all between-day coefficients of variation were below 7% and the recovery rates were between 60 and 103%. Using 1 ml of serum, the lower limits of quantification were between 1.2 and 54 nmol/l for the different drugs and below the therapeutic range for each of the different drugs.

About the article

Published Online: 2005-06-01

Published in Print: 2003-12-04

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 12, Pages 1571–1579, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.240.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Sarah M. R. Wille, Sarah G. Cooreman, Hugo M. Neels, and Willy E. E. Lambert
Critical Reviews in Clinical Laboratory Sciences, 2008, Volume 45, Number 1, Page 25
Jingjing Wang, Hua Huang, Qin Yao, Yang Lu, Qiaoling Zheng, Yuqi Cheng, Xiufeng Xu, Qiong Zhou, Di Wu, Min Zhang, Xiaosu Li, and Jun Zhang
Therapeutic Drug Monitoring, 2015, Volume 37, Number 5, Page 649
Julieta Gradinaru, Astrid Vullioud, Chin B. Eap, and Nicolas Ansermot
Journal of Pharmaceutical and Biomedical Analysis, 2014, Volume 88, Page 36
Muhammad Naeem Khan, Muhammad Rasul Jan, Jasmin Shah, and Sang Hak Lee
Luminescence, 2014, Volume 29, Number 3, Page 266
Lisbeth Patteet, Manuel Morrens, Kristof E. Maudens, Peter Niemegeers, Bernard Sabbe, and Hugo Neels
Therapeutic Drug Monitoring, 2012, Volume 34, Number 6, Page 629
Pierre Baumann, Hartmut Kirchherr, Patricia Berney, and Christoph Hiemke
Psychopharmacology, 2012, Volume 221, Number 4, Page 719
Eva Saar, Jochen Beyer, Dimitri Gerostamoulos, and Olaf H. Drummer
Drug Testing and Analysis, 2012, Volume 4, Number 6, Page 376
Naser Shraim, Ralph Clinckers, Sophie Sarre, Yvette Michotte, and Ann Van Eeckhaut
Journal of Chromatography B, 2012, Volume 898, Page 53
Ana de Castro, Maria del Mar Ramírez Fernandez, Marleen Laloup, Nele Samyn, Gert De Boeck, Michelle Wood, Viviane Maes, and Manuel López-Rivadulla
Journal of Chromatography A, 2007, Volume 1160, Number 1-2, Page 3
Molly L. Rovin, Katherine A. Boss-Williams, Reid S. Alisch, James C. Ritchie, David Weinshenker, Charles H.K. West, and Jay M. Weiss
Neuropeptides, 2012, Volume 46, Number 2, Page 81
Heidrun Appl, Tobias Holzammer, Stefan Dove, Ekkehard Haen, Andrea Straßer, and Roland Seifert
Naunyn-Schmiedeberg's Archives of Pharmacology, 2012, Volume 385, Number 2, Page 145
Tatsuo Shinozuka, Masaru Terada, and Einosuke Tanaka
Forensic Science International, 2006, Volume 162, Number 1-3, Page 108
Jinjing Che, Qingfang Meng, Zhihang Chen, Chengqi San, Yunan Hou, and Yuanguo Cheng
Journal of Pharmaceutical and Biomedical Analysis, 2007, Volume 45, Number 5, Page 785
Robert Skibiński and Genowefa Misztal
Journal of Liquid Chromatography & Related Technologies, 2005, Volume 28, Number 2, Page 313
Journal of Chromatography B, 2004, Volume 810, Number 2, Page 235
Henri P. A. Nouws, Cristina Delerue‐Matos, and Aquiles A. Barros
Analytical Letters, 2006, Volume 39, Number 9, Page 1907
Eva Choong, Serge Rudaz, Astrid Kottelat, Sophie Haldemann, Davy Guillarme, Jean-Luc Veuthey, and Chin B. Eap
Journal of Chromatography B, 2011, Volume 879, Number 19, Page 1544
Zühre Şentürk, Cafer Saka, and İbrahim Teğin
Reviews in Analytical Chemistry, 2011, Volume 30, Number 2
Sunil Bajad and Vladimir Shulaev
TrAC Trends in Analytical Chemistry, 2007, Volume 26, Number 6, Page 625
O. Yu. Kravtsova and I. I. Miroshnichenko
Pharmaceutical Chemistry Journal, 2011, Volume 44, Number 11, Page 628
Sarah M.R. Wille, Kristof E. Maudens, Carlos H. Van Peteghem, and Willy E.E. Lambert
Journal of Chromatography A, 2005, Volume 1098, Number 1-2, Page 19
G.M. Fiedler, U. Ceglarek, J. Lembcke, S. Baumann, A. Leichtle, and J. Thiery
LaboratoriumsMedizin, 2004, Volume 28, Number 3, Page 185
Juan José Berzas Nevado, Carmen Guiberteau Cabanillas, María Jesús Villaseñor Llerena, and Virginia Rodríguez Robledo
Journal of Chromatography A, 2005, Volume 1072, Number 2, Page 249
Nora Unceta, M. Aranzazu Goicolea, and Ramón J. Barrio
Biomedical Chromatography, 2011, Volume 25, Number 1-2, Page 238
Daniela Remane, Markus R. Meyer, Frank T. Peters, Dirk K. Wissenbach, and Hans H. Maurer
Analytical and Bioanalytical Chemistry, 2010, Volume 397, Number 6, Page 2303
Charles H. K. West, James C. Ritchie, Katherine A. Boss-Williams, and Jay M. Weiss
The International Journal of Neuropsychopharmacology, 2009, Volume 12, Number 05, Page 627
Xiao-Cong Zuo, Bi-Kui Zhang, Ben-Mei Chen, Shao-Gang Liu, Guo-Ping Yang, Shi-Kun Liu, Shao-Qian Liu, Zhi-Jun Huang, and Hong Yuan
Chromatographia, 2009, Volume 69, Number 3-4, Page 301
Christoph Hiemke
European Archives of Psychiatry and Clinical Neuroscience, 2008, Volume 258, Number S1, Page 21
Christoph Hiemke
European Journal of Clinical Pharmacology, 2008, Volume 64, Number 2, Page 159
Olaf H. Drummer
Analytical and Bioanalytical Chemistry, 2007, Volume 388, Number 7, Page 1495
Laura Mercolini, Maria Grillo, Claudio Bartoletti, Giancarlo Boncompagni, and Maria Augusta Raggi
Analytical and Bioanalytical Chemistry, 2007, Volume 388, Number 1, Page 235
W. Franklin Smyth, Julian C. Leslie, Stephen McClean, Bernadette Hannigan, Hugh P. McKenna, Bernadette Doherty, Clare Joyce, and Edmund O'Kane
Rapid Communications in Mass Spectrometry, 2006, Volume 20, Number 11, Page 1637
F L Sauvage, J M Gaulier, G Lach??tre, and P Marquet
Therapeutic Drug Monitoring, 2006, Volume 28, Number 1, Page 123
Teresa Galeano-Díaz, María-Isabel Acedo-Valenzuela, Nielene Mora-Díez, and Antonio Silva-Rodríguez
ELECTROPHORESIS, 2005, Volume 26, Number 18, Page 3518
Henri P. A. Nouws, Cristina Delerue-Matos, Aquiles A. Barros, José A. Rodrigues, and Alice Santos-Silva
Analytical and Bioanalytical Chemistry, 2005, Volume 382, Number 7, Page 1662

Comments (0)

Please log in or register to comment.
Log in