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Licensed Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

Glutathione Peroxidase Activity and Serum Selenium Concentration in Intrinsic Asthmatic Patients

  • Durdi Qujeq , Behzad Hidari , Khezroolla Bijani and Hosein Shirdel

Abstract

Serum glutathione peroxidase (GSH-Px) activity and selenium concentration were compared in intrinsic asthmatic patients and non-asthmatic control subjects. Serum GSH-Px activity and selenium concentration were assessed in 46 asthmatic patients and 75 age- and sex-matched non-asthmatic subjects by spectrophotometric assay. Mean serum GSH-Px activity was lower in intrinsic asthmatic subjects (9.4±2.6 μmol NADPH oxidized/min/g of protein) than in non-asthmatic subjects (16.3±2.9 μmol NADPH oxidized/min/g of protein). Mean serum selenium was lower in intrinsic asthmatic subjects (1.15±0.23 μM) than in non-asthmatic subjects (1.98±0.27 μM). Asthmatic patients have significantly lower concentration of selenium and GSH-Px activity measured in serum.

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Published Online: 2005-06-01
Published in Print: 2003-02-21

Copyright © 2003 by Walter de Gruyter GmbH & Co. KG

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