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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1434-6621
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Volume 41, Issue 4

Issues

Molecular Diagnostics by Microelectronic Microchips

Maurizio Ferrari / Stefania Stenirri / Pierangelo Bonini / Laura Cremonesi
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.069

Abstract

Molecular diagnostics is being revolutionized by the completion of the human genome project and by the development of highly advanced technologies for DNA testing. One of the most important challenges is the introduction of high throughput systems such as DNA chips into diagnostic laboratories. DNA microchips are small devices permitting rapid analysis of genetic information, exploiting miniaturization of all components and automation of operational procedures. The most important biochip applications include gene expression and genetic variation identification and both may improve human molecular diagnostics. Here we review several approaches developed to allow rapid detection of many single nucleotide polymorphisms and mutations in large population samples. Among these, the use of microelectronics seems to best fit with the needs of molecular diagnostics.

About the article

Published Online: 2005-06-01

Published in Print: 2003-04-25


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 4, Pages 462–467, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.069.

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[2]
Stefania Stenirri, Georgia Alaimo, Maria Pia Manitto, Rosario Brancato, Maurizio Ferrari, and Laura Cremonesi
Clinical Chemistry and Laboratory Medicine, 2008, Volume 46, Number 9
[3]
Christos Shammas, Thessalia Papasavva, Xenia Felekis, Christos Christophorou, Hanno Roomere, Jan Traeger Synodinos, Emmanuel Kanavakis, Mohammed El-Khateeb, Hanan Hamamy, Tamara Mahmoud, Mohammad Shboul, Amal El Beshlawy, Dvora Filon, Ibtessam R. Hussein, Renzo Galanello, Giovanni Romeo, and Marina Kleanthous
Clinical Chemistry and Laboratory Medicine, 2010, Volume 48, Number 12
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Francesca Ferrari, Barbara Foglieni, Paolo Arosio, Clara Camaschella, Filomena Daraio, Sonia Levi, José Antonio García Erce, Carole Beaumont, Mario Cazzola, Maurizio Ferrari, and Laura Cremonesi
Human Mutation, 2006, Volume 27, Number 2, Page 201

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