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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 41, Issue 4


Molecular Diagnostics by Microelectronic Microchips

Maurizio Ferrari / Stefania Stenirri / Pierangelo Bonini / Laura Cremonesi
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.069


Molecular diagnostics is being revolutionized by the completion of the human genome project and by the development of highly advanced technologies for DNA testing. One of the most important challenges is the introduction of high throughput systems such as DNA chips into diagnostic laboratories. DNA microchips are small devices permitting rapid analysis of genetic information, exploiting miniaturization of all components and automation of operational procedures. The most important biochip applications include gene expression and genetic variation identification and both may improve human molecular diagnostics. Here we review several approaches developed to allow rapid detection of many single nucleotide polymorphisms and mutations in large population samples. Among these, the use of microelectronics seems to best fit with the needs of molecular diagnostics.

About the article

Published Online: 2005-06-01

Published in Print: 2003-04-25

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 4, Pages 462–467, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.069.

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