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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Hrsg. v. Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Band 41, Heft 4

Hefte

Molecular Diagnostics by Microelectronic Microchips

Maurizio Ferrari / Stefania Stenirri / Pierangelo Bonini / Laura Cremonesi
Online erschienen: 01.06.2005 | DOI: https://doi.org/10.1515/CCLM.2003.069

Abstract

Molecular diagnostics is being revolutionized by the completion of the human genome project and by the development of highly advanced technologies for DNA testing. One of the most important challenges is the introduction of high throughput systems such as DNA chips into diagnostic laboratories. DNA microchips are small devices permitting rapid analysis of genetic information, exploiting miniaturization of all components and automation of operational procedures. The most important biochip applications include gene expression and genetic variation identification and both may improve human molecular diagnostics. Here we review several approaches developed to allow rapid detection of many single nucleotide polymorphisms and mutations in large population samples. Among these, the use of microelectronics seems to best fit with the needs of molecular diagnostics.

Artikelinformationen

Online erschienen: 01.06.2005

Erschienen im Druck: 25.04.2003


Quellenangabe: Clinical Chemistry and Laboratory Medicine, Band 41, Heft 4, Seiten 462–467, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.069.

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[2]
Stefania Stenirri, Georgia Alaimo, Maria Pia Manitto, Rosario Brancato, Maurizio Ferrari, and Laura Cremonesi
Clinical Chemistry and Laboratory Medicine, 2008, Jahrgang 46, Nummer 9
[3]
Christos Shammas, Thessalia Papasavva, Xenia Felekis, Christos Christophorou, Hanno Roomere, Jan Traeger Synodinos, Emmanuel Kanavakis, Mohammed El-Khateeb, Hanan Hamamy, Tamara Mahmoud, Mohammad Shboul, Amal El Beshlawy, Dvora Filon, Ibtessam R. Hussein, Renzo Galanello, Giovanni Romeo, and Marina Kleanthous
Clinical Chemistry and Laboratory Medicine, 2010, Jahrgang 48, Nummer 12
[4]
Francesca Ferrari, Barbara Foglieni, Paolo Arosio, Clara Camaschella, Filomena Daraio, Sonia Levi, José Antonio García Erce, Carole Beaumont, Mario Cazzola, Maurizio Ferrari, and Laura Cremonesi
Human Mutation, 2006, Jahrgang 27, Nummer 2, Seite 201

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