Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 41, Issue 4

Issues

Lipoprotein Lipase Gene Polymorphisms in Croatian Patients with Coronary Artery Disease

Goran Ferenčak / Daria Pašalić / Branka Grškovic / Suzanne Cheng / Bonnie Fijal / Mihajlo Šesto / Jasna Skodla / Ana Stavljenić Rukavina
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.082

Abstract

Modifications in lipoprotein lipase levels lead to elevated triglycerides and reduced high density lipoprotein (HDL), both of which are risk factors for coronary artery disease (CAD). Hence, we examined the influence of the −93T/G, D9N, N291S, and S447X polymorphisms in the lipoprotein lipase (LPL) gene on CAD risk and lipid levels in Croatian patients with and without angiographically confirmed CAD. The N291S polymorphism was significantly associated with CAD (OR = 0.36; 95% CI = 0.13, 0.99; p = 0.048). This association was only moderately affected by adjusting for various lipids (OR = 0.36; 95% CI = 0.12, 1.08; p = 0.068). HDL2-cholesterol and apolipoprotein A-I levels were significantly higher in non-carriers of the −93T/G and D9N polymorphisms in the CAD group (p = 0.017 and 0.028, respectively). The N291S genetic variant did not show any significant difference between carriers and non-carriers in either group studied for any of the lipids. Lower triglyceride and higher HDL2-cholesterol levels in the control group were associated with carriers of the S447X mutation (p = 0.043 and 0.056, respectively). LPL gene polymorphisms might be involved in predisposition to CAD and determination of lipid profiles.

About the article

Published Online: 2005-06-01

Published in Print: 2003-04-25


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 4, Pages 541–546, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.082.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Weiping Sun, Yongquan Wu, Yumei Wen, Ming Guo, and Haibin Zhang
Minerva Cardioangiologica, 2019, Volume 67, Number 3
[2]
Wen-Qi Ma, Ying Wang, Xi-Qiong Han, Yi Zhu, and Nai-Feng Liu
Bioscience Reports, 2018, Volume 38, Number 2, Page BSR20171642
[3]
Olga W Souverein, J Wouter Jukema, S Matthijs Boekholdt, Aeilko H Zwinderman, and Michael W T Tanck
European Journal of Human Genetics, 2005, Volume 13, Number 4, Page 445
[4]
MOHAMED S. DAOUD, FARID S. ATAYA, DALIA FOUAD, AMAL ALHAZZANI, AFAF I. SHEHATA, and ABDULAZIZ A. AL-JAFARI
Biomedical Reports, 2013, Volume 1, Number 4, Page 573
[5]
Yaomin Hu, Wei Liu, Rong Huang, and Xiaoying Zhang
Journal of Lipid Research, 2006, Volume 47, Number 9, Page 1908
[6]
Li Xie and You-Mei Li
International Journal of Environmental Research and Public Health, 2017, Volume 14, Number 1, Page 84
[7]
Lamia Rebhi, Kaouther Kchok, Asma Omezzine, Slim Kacem, Jihène Rejeb, Ibtihel Ben HadjMbarek, Radhia Belkahla, Imen Boumaiza, Amira Moussa, Nabila Ben Rejeb, Naoufel Nabli, Essia Boughzala, Ahmed Ben Abdelaziz, and Ali Bouslama
Molecular Biology Reports, 2012, Volume 39, Number 11, Page 9893
[8]
Rajneesh Tripathi, Sarita Agarwal, and Venkataraman Ramesh
Biochemical Genetics, 2011, Volume 49, Number 9-10, Page 587
[9]
Daria Pašalić, Zvonko Jurčić, Gordana Stipančić, Goran Ferenčak, Trond P. Leren, Srdjan Djurovic, and Ana Stavljenić-Rukavina
Clinica Chimica Acta, 2004, Volume 343, Number 1-2, Page 179
[10]
Selçuk Matyar, Gülen Attila, Esmeray Acartürk, Onur Akpinar, and Tamer İnal
Clinica Chimica Acta, 2005, Volume 354, Number 1-2, Page 153
[11]
Larry Baum, Ho Keung Ng, Ka Sing Wong, Brian Tomlinson, Timothy Hudson Rainer, Xiangyan Chen, Wing Sze Cheung, Jinling Tang, Wilson Wai San Tam, William Goggins, Cindy See Wai Tong, Daniel Kam Yin Chan, G. Neil Thomas, Ping Chook, and Kam Sang Woo
Clinical Chemistry and Laboratory Medicine (CCLM), 2006, Volume 44, Number 3
[12]
G. S. Sagoo, I. Tatt, G. Salanti, A. S. Butterworth, N. Sarwar, M. van Maarle, J. W. Jukema, B. Wiman, J. J. P. Kastelein, A. M. Bennet, U. de Faire, J. Danesh, and J. P. T. Higgins
American Journal of Epidemiology, 2008, Volume 168, Number 11, Page 1233
[13]
V. A. Sukhanov and L. A. Piruzyan
Human Physiology, 2006, Volume 32, Number 3, Page 334

Comments (0)

Please log in or register to comment.
Log in