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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 41, Issue 7

Issues

Tryptophan Metabolites and Brain Disorders

Trevor W. Stone / Gillian M. Mackay / Caroline M. Forrest / Catherine J. Clark / L. Gail Darlington
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.129

Abstract

Tryptophan is metabolised primarily along the kynurenine pathway, of which two components are now known to have marked effects on neurons in the central nervous system. Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors. Consequently quinolinic acid can act as a neurotoxin while kynurenic acid is neuroprotectant. A third kynurenine, 3-hydroxykynurenine, can generate free radicals and contribute to, or exacerbate, neuronal damage. Changes in the absolute or relative concentrations of these kynurenines have been implicated in a variety of central nervous system disorders such as the AIDS-dementia complex and Huntington's disease, raising the possibility that interference with their actions or synthesis could lead to new forms of pharmacotherapy for these conditions.

About the article

Published Online: 2005-06-01

Published in Print: 2003-07-21


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 7, Pages 852–859, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.129.

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[20]
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[21]
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[22]
Free Radical Research, 2008, Volume 42, Number sup1, Page S2
[23]
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[24]
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[25]
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[26]
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[27]
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[28]
Leticia M. Toledo-Sherman, Michael E. Prime, Ladislav Mrzljak, Maria G. Beconi, Alan Beresford, Frederick A. Brookfield, Christopher J. Brown, Isabell Cardaun, Stephen M. Courtney, Ulrike Dijkman, Estelle Hamelin-Flegg, Peter D. Johnson, Valerie Kempf, Kathy Lyons, Kimberly Matthews, William L. Mitchell, Catherine O’Connell, Paula Pena, Kendall Powell, Arash Rassoulpour, Laura Reed, Wolfgang Reindl, Suganathan Selvaratnam, Weslyn Ward Friley, Derek A. Weddell, Naomi E. Went, Patricia Wheelan, Christin Winkler, Dirk Winkler, John Wityak, Christopher J. Yarnold, Dawn Yates, Ignacio Munoz-Sanjuan, and Celia Dominguez
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[29]
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[30]
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Neuroscience, 2015, Volume 285, Page 97
[31]
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[32]
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Biochemical and Biophysical Research Communications, 2014, Volume 450, Number 1, Page 25
[33]
C Chojnacki, E Walecka-Kapica, A Stepien, M Pawlowicz, P Wachowska-Kelly, and J Chojnacki
Advances in Medical Sciences, 2013, Volume 58, Number 2, Page 251
[34]
A.L. Colín-González, A. Luna-López, M. Königsberg, S.F. Ali, J. Pedraza-Chaverrí, and A. Santamaría
Neuroscience, 2014, Volume 260, Page 130
[36]
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[37]
Marta Amaral, Tiago F. Outeiro, Nigel S. Scrutton, and Flaviano Giorgini
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[38]
Sunoh Kwon, Bombi Lee, Mijung Yeom, Bong-Jun Sur, Myunghwan Kim, Seung-Tae Kim, Hi-Joon Park, Hyejung Lee, and Dae-Hyun Hahm
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[39]
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[40]
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[41]
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[42]
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[43]
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[45]
Tomasz Kocki, Sebastian Wnuk, Renata Kloc, Janusz Kocki, Björn Owe-Larsson, and Ewa M. Urbanska
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[46]
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[47]
K. Nagy, I. Plangár, B. Tuka, L. Gellért, D. Varga, I. Demeter, T. Farkas, Zs. Kis, M. Marosi, D. Zádori, P. Klivényi, F. Fülöp, I. Szatmári, L. Vécsei, and J. Toldi
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[48]
Oscar D. Cano, Gabriele Neurauter, Dietmar Fuchs, Gene M. Shearer, and Adriano Boasso
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[49]
David Meininger, Leeanne Zalameda, Yichin Liu, Lara P. Stepan, Luis Borges, John D. McCarter, and Claire L. Sutherland
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[50]
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[51]
Daniela Krause, Hyeon-Sook Suh, Leonid Tarassishin, Qiao Ling Cui, Bryce A. Durafourt, Namjong Choi, Avital Bauman, Melissa Cosenza-Nashat, Jack P. Antel, Meng-Liang Zhao, and Sunhee C. Lee
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[52]
Cynthia L. Bethea, Arubala P. Reddy, Yukari Tokuyama, Jessica A. Henderson, and Fernanda B. Lima
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[53]
Eniko Vamos, Arpad Pardutz, Peter Klivenyi, Jozsef Toldi, and Laszlo Vecsei
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[54]
Katalin Sas, Hermina Robotka, József Toldi, and László Vécsei
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[55]
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[56]
Hermina Robotka, Hajnalka Németh, Csaba Somlai, László Vécsei, and József Toldi
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[57]
Vasily N. Dobrovolsky, John F. Bowyer, Michael K. Pabarcus, Robert H. Heflich, Lee D. Williams, Daniel R. Doerge, Björn Arvidsson, Jonas Bergquist, and John E. Casida
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[58]
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[59]
Guilhian Leipnitz, Cristiana Schumacher, Karina B. Dalcin, Karina Scussiato, Alexandre Solano, Cláudia Funchal, Carlos S. Dutra-Filho, Angela T.S. Wyse, Clóvis M.D. Wannmacher, Alexandra Latini, and Moacir Wajner
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[60]
K. Schroecksnadel, M. Sarcletti, C. Winkler, B. Mumelter, G. Weiss, D. Fuchs, G. Kemmler, and R. Zangerle
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[61]
Nicholas H. Hunt, Jacob Golenser, Tailoi Chan-Ling, Sapan Parekh, Caroline Rae, Sarah Potter, Isabelle M. Medana, Jenny Miu, and Helen J. Ball
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[62]
H. Németh, H. Robotka, Z. Kis, É. Rózsa, T. Janáky, C. Somlai, M. Marosi, T. Farkas, J. Toldi, and L. Vécsei
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[63]
Caroline L. Bellac, Roney S. Coimbra, Stephan Christen, and Stephen L. Leib
Neurobiology of Disease, 2006, Volume 24, Number 2, Page 395
[64]
Fladjule Rejane Soares de Souza, Fabrícia Lima Fontes, Thayse Azevedo da Silva, Leonam Gomes Coutinho, Stephen L Leib, and Lucymara Fassarella Agnez-Lima
BMC Medical Genetics, 2011, Volume 12, Number 1
[65]
J. Tajti, Á. Párdutz, E. Vámos, B. Tuka, A. Kuris, Zs. Bohár, A. Fejes, J. Toldi, and L. Vécsei
Journal of Neural Transmission, 2011, Volume 118, Number 4, Page 511
[66]
[67]
Hermina Robotka, József Toldi, and László Vécsei
Future Neurology, 2008, Volume 3, Number 2, Page 169
[68]
E Gulaj, K Pawlak, B Bien, and D Pawlak
Advances in Medical Sciences, 2010, Volume 55, Number 2, Page 204
[69]
Caroline L. Bellac, Roney S. Coimbra, Stephan Christen, and Stephen L. Leib
Journal of Neuropathology & Experimental Neurology, 2010, Volume 69, Number 11, Page 1096
[70]
Raf Brouns, Robert Verkerk, Tony Aerts, Didier De Surgeloose, Annick Wauters, Simon Scharpé, and Peter P. De Deyn
Neurochemical Research, 2010, Volume 35, Number 9, Page 1315
[71]
David J. Bonda, Maneesh Mailankot, Jeremy G. Stone, Matthew R. Garrett, Magdalena Staniszewska, Rudy J. Castellani, Sandra L. Siedlak, Xiongwei Zhu, Hyoung-gon Lee, George Perry, Ram H. Nagaraj, and Mark A. Smith
Redox Report, 2010, Volume 15, Number 4, Page 161
[72]
Christopher Jonathan Daraius Austin, B. M. Mailu, G. J. Maghzal, A. Sanchez-Perez, S. Rahlfs, K. Zocher, H. J. Yuasa, J. W. Arthur, K. Becker, R. Stocker, N. H. Hunt, and H. J. Ball
Amino Acids, 2010, Volume 39, Number 2, Page 565
[73]
Bożena Muszyńska, Anna Maślanka, Katarzyna Sułkowska-Ziaja, and Jan Krzek
Journal of Planar Chromatography – Modern TLC, 2007, Volume 20, Number 1, Page 57
[74]
Gillian M. Mackay ., Caroline M. Forrest ., Stuart R. Gould ., and Trevor W. Stone .
Journal of Medical Sciences(Faisalabad), 2004, Volume 4, Number 4, Page 246
[75]
Qian Han, Tao Cai, Danilo A. Tagle, and Jianyong Li
Cellular and Molecular Life Sciences, 2010, Volume 67, Number 3, Page 353
[76]
Jessica Gätjens, Christopher S. Mullins, Jeff W. Kampf, Pierre Thuéry, and Vincent L. Pecoraro
Dalton Trans., 2009, Number 1, Page 51
[77]
Catarina Figueiredo, Teresa F. Pais, João R. Gomes, and Sukalyan Chatterjee
Journal of Neurochemistry, 2008, Volume 107, Number 1, Page 73
[78]
Patrícia Fernanda Schuck, Anelise Tonin, Gustavo da Costa Ferreira, Carolina Maso Viegas, Alexandra Latini, Clovis Milton Duval Wannmacher, Angela Terezinha de Souza Wyse, Carlos Severo Dutra-Filho, and Moacir Wajner
Cellular and Molecular Neurobiology, 2007, Volume 27, Number 1, Page 147
[79]
j. kaszaki, z. palásthy, d. érczes, a. rácz, c. torday, g. varga, l. vécsei, and m. boros
Neurogastroenterology & Motility, 2007, Volume 0, Number 0, Page 070831062145001
[81]
Jolon M. Dyer, Scott D. Bringans, and Warren G. Bryson
Photochemistry and Photobiology, 2006, Volume 82, Number 2, Page 551
[82]
César A. J. Ribeiro, Vanessa Grando, Carlos S. Dutra Filho, Clóvis M. D. Wannmacher, and Moacir Wajner
Journal of Neurochemistry, 2006, Volume 99, Number 6, Page 1531
[83]
L. K. Nilsson, K. R. Linderholm, and S. Erhardt
Journal of Neural Transmission, 2006, Volume 113, Number 5, Page 557
[84]
J. Christofides, M. Bridel, M. Egerton, G. M. Mackay, C. M. Forrest, N. Stoy, L. G. Darlington, and T. W. Stone
Journal of Neurochemistry, 2006, Volume 97, Number 4, Page 1078
[85]
Franca Rossi, Fabrizio Lombardo, Alessandra Paglino, Camilla Cassani, Gianluca Miglio, Bruno Arca, and Menico Rizzi
FEBS Journal, 2005, Volume 272, Number 21, Page 5653
[86]
Arubala P. Reddy and Cynthia L. Bethea
Psychopharmacology, 2005, Volume 180, Number 1, Page 125

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