Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 41, Issue 7


The Role of Interleukin-4 and Interleukin-13 in the Non-Immunologic Aspects of Asthma Pathogenesis

Kenji Izuhara
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.130


Bronchial asthma is a complex disease characterized by airway inflammation involving a Th2-cytokine, interleukin (IL)-13. A substantial body of evidence has accumulated pointing to the pivotal role of IL-13 in the pathogenesis of bronchial asthma. The evidence is categorized as (i) analyses of mouse models, (ii) expression of these cytokines in the bronchial lesions, and (iii) genetic association of the signaling molecules of these cytokines. In addition, the molecular mechanism of the signal transduction of IL-13 has also been well characterized. We have applied microarray analyses to human bronchial epithelial cultures to search for genes regulated by IL-13 and have identified a subset of disease-relevant genes by comparison with cDNA libraries derived from normal and asthmatic bronchial biopsies. Expression of squamous cell carcinoma antigen-1 (SCCA1) and SCCA2, the cysteine and serine protease inhibitors, respectively, was the highest in the bronchial epithelial cells stimulated by IL-4 and IL-13 and was augmented in the asthmatic cDNA library. Furthermore, serum levels of SCCA were also elevated in asthmatic patients. Taken together, it was supposed that SCCA may play some role in the pathogenesis of bronchial asthma, and measuring its serum level may be relevant for diagnosing or monitoring the status of bronchial asthma.

About the article

Published Online: 2005-06-01

Published in Print: 2003-07-21

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 7, Pages 860–864, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.130.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Satoshi Takeuchi, Norihiro Furusyo, Junya Ono, Yoshinori Azuma, Masaki Takemura, Hitokazu Esaki, Kazuhiko Yamamura, Yasutaka Mitamura, Gaku Tsuji, Mari Kiyomatsu-Oda, Jun Hayashi, Kenji Izuhara, and Masutaka Furue
Journal of Dermatological Science, 2019, Volume 95, Number 2, Page 70
Atsumi Yamaguchi, Tomoko Fujitani, Ken-ichi Ohyama, Dai Nakae, Akihiko Hirose, Tetsuji Nishimura, and Akio Ogata
The Journal of Toxicological Sciences, 2012, Volume 37, Number 1, Page 177
Shoichi Suzuki, Masahiro Ogawa, Shoichiro Ohta, Satoshi Nunomura, Yasuhiro Nanri, Hiroshi Shiraishi, Yasutaka Mitamura, Tomohito Yoshihara, James J. Lee, and Kenji Izuhara
Journal of Biological Chemistry, 2016, Volume 291, Number 53, Page 27219
Rabindranath Ray, Moonsuk Choi, Zhongjian Zhang, Gary A. Silverman, David Askew, and Anil B. Mukherjee
Journal of Biological Chemistry, 2005, Volume 280, Number 11, Page 9761
David J. Askew, Sule Cataltepe, Vasantha Kumar, Christopher Edwards, Serena M. Pace, Rica N. Howarth, Stephen C. Pak, Yuko S. Askew, Dieter Brömme, Cliff J. Luke, James C. Whisstock, and Gary A. Silverman
Journal of Biological Chemistry, 2007, Volume 282, Number 34, Page 24948
Yu Sun, Namratha Sheshadri, and Wei-Xing Zong
Seminars in Cell & Developmental Biology, 2017, Volume 62, Page 170
Annie Chamberland, Anne-Marie Madore, Karine Tremblay, Michel Laviolette, and C. Laprise
Experimental Lung Research, 2009, Volume 35, Number 5, Page 399
Yoon Hee Kim, Miki Yoshimoto, Kazuko Nakayama, Sousuke Tanino, Yoshinori Fujimura, Koji Yamada, and Hirofumi Tachibana
FEBS Open Bio, 2013, Volume 3, Number 1, Page 341
Tzu-Hui Li, Yi-Fen Kao, Chun-Chung Lui, and Wei-Hsi Chen
Clinical Biochemistry, 2006, Volume 39, Number 6, Page 662
Song-Chul Park, Seung Hyun Koh, Sang Heon Lee, and Jae Hoon Lee
Korean Journal of Otolaryngology-Head and Neck Surgery, 2009, Volume 52, Number 3, Page 228
Geraldine F. Clough, Claire L. Jackson, Jacob J.P. Lee, Sarah C. Jamal, and Martin K. Church
Journal of Investigative Dermatology, 2007, Volume 127, Number 12, Page 2799
Marsha Wills- Karp
Current Allergy and Asthma Reports, 2004, Volume 4, Number 2, Page 123

Comments (0)

Please log in or register to comment.
Log in