Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 41, Issue 7

Issues

Polymorphisms in the IL-4 and IL-4R [α] Genes and Allergic Asthma

Tianpen Cui / Jianmin Wu / Shixiu Pan / Jungang Xie
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.134

Abstract

Allergic asthma is caused by genetic and environmental factors that interact to determine disease susceptibility and severity. Several lines of evidence suggest that the interleukin (IL)-4 gene and the IL-4-receptor α (IL-4Rα) gene are involved in the development of atopic diseases. We sought to determine whether two polymorphism sites in IL-4 and IL-4Rα chain were associated with allergic asthma in a Chinese population. We obtained DNA and clinical data from allergic asthma patients, which were compared with those of a group of healthy control subjects. The subjects were genotyped for the IL-4 C-590T promoter polymorphism and the IL-4R α chain Q576R by polymerase chain reaction-restriction fragment length polymorphism. The results showed that the IL-4 C-590T was not associated with allergic asthma in a Chinese population. However, the IL-4R α chain 576R/R was significantly increased in allergic asthma patients compared with control subjects (χ2=21.16; p < 0.01), and also total plasma immunoglobulin E (IgE) level was increased in allergic asthma patients. These data suggest that the IL-4R α chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese.

About the article

Published Online: 2005-06-01

Published in Print: 2003-07-21


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 7, Pages 888–892, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.134.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Xiaobo Li, Yonggang Zhang, Jie Zhang, Yuling Xiao, Jin Huang, Can Tian, Chao He, Yao Deng, Yingying Yang, and Hong Fan
Respiratory Research, 2010, Volume 11, Number 1
[2]
Hong Shang, Xiu-Li Cao, Yu-Jie Wan, Jin Meng, and Lu-Hong Guo
Disease Markers, 2016, Volume 2016, Page 1
[3]
Beata Narożna, Aleksandra Hoffmann, Paulina Sobkowiak, Natalia Schoneich, Anna Bręborowicz, and Aleksandra Szczepankiewicz
Advances in Medical Sciences, 2016, Volume 61, Number 1, Page 40
[4]
Pratibha Dixit, Shally Awasthi, and Sarita Agarwal
Annals of Human Biology, 2015, Volume 42, Number 6, Page 552
[6]
Chi-Huei Chiang, Ming-Wei Lin, Ming-Yi Chung, and Ueng-Cheng Yang
Journal of the Chinese Medical Association, 2012, Volume 75, Number 12, Page 635
[7]
Ya-fei LI, Bo-tao GUO, Jia-xin HAN, Cai-zhong ZHU, Yao ZHANG, Xiang-yu MA, Lu ZHANG, and Hong-yan XIONG
Journal of Medical Colleges of PLA, 2007, Volume 22, Number 5, Page 312
[8]
Matthew J. Loza and Bao-Li Chang
Journal of Allergy and Clinical Immunology, 2007, Volume 120, Number 3, Page 578
[9]
Yafei Li, Botao Guo, Lin Zhang, Jiaxin Han, Bo Wu, and Hongyan Xiong
Respiratory Medicine, 2008, Volume 102, Number 7, Page 984
[10]
Deborah A Gentile, William J Doyle, Adriana Zeevi, Judith Howe-Adams, Jordan Trecki, and David P Skoner
Human Immunology, 2004, Volume 65, Number 4, Page 347
[11]
Stefano Landi, Fabio Bottari, Federica Gemignani, Lydie Gioia-Patricola, Elisabeth Guino, Alfonso Osorio, Javier de Oca, Gabriel Capella, Federico Canzian, and Victor Moreno
European Journal of Cancer, 2007, Volume 43, Number 4, Page 762
[12]
S. L. EWART and N. E. ROBINSON
Equine Veterinary Journal, 2007, Volume 39, Number 3, Page 270
[13]
Mahdi Bijanzadeh, Nallur B. Ramachandra, P. A. Mahesh, R. Savitha Mysore, Pradeep Kumar, B. S. Manjunath, and B. S. Jayaraj
Lung, 2010, Volume 188, Number 5, Page 415
[14]
June E. Swinburne, Helen Bogle, Jolanta Klukowska-Rötzler, Michaela Drögemüller, Tosso Leeb, Elizabeth Temperton, Gaudenz Dolf, and Vincent Gerber
Mammalian Genome, 2009, Volume 20, Number 8, Page 504
[15]
Uwe Müller, Werner Stenzel, Gabriele Köhler, Tobias Polte, Manfred Blessing, Amrit Mann, Daniel Piehler, Frank Brombacher, and Gottfried Alber
The Journal of Infectious Diseases, 2008, Volume 198, Number 11, Page 1714
[16]
Jeong Joong Kim, Jung Youl Min, and Jae Hoon Lee
European Archives of Oto-Rhino-Laryngology, 2007, Volume 264, Number 4, Page 395
[17]
Chi-Huei CHIANG, Ying-Chuan TANG, Ming-Wei LIN, and Ming-Yi CHUNG
Respirology, 2007, Volume 12, Number 1, Page 42
[18]
Johanna de Groot, Leo Kruijt, Jan Willem Scholten, Wim J. A. Boersma, Willem G. Buist, Bas Engel, and Cornelis G. van Reenen
Immunology, 2005, Volume 115, Number 4, Page 495
[19]
Izolda Franjkovic, Andre Gessner, Inke K�nig, Karin Kissel, Anette Bohnert, Anne Hartung, Astrid Ohly, Andreas Ziegler, Holger Hackstein, and Gregor Bein
Immunogenetics, 2005, Volume 56, Number 11, Page 808
[20]
Byung Lae Park, Lyoung Hyo Kim, Yoo Hyun Choi, June-Hyuk Lee, Taiyoun Rhim, Young Mok Lee, Soo-Taek Uh, Hae-Sim Park, Byoung Whui Choi, Soo-Jong Hong, Choon-Sik Park, and Hyoung Doo Shin
Journal of Human Genetics, 2004, Volume 49, Number 10, Page 517

Comments (0)

Please log in or register to comment.
Log in