Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 41, Issue 7


Effect of Different Dialysis Membranes on Erythrocyte Antioxidant Enzyme Levels and Scavenger Systems Related to Free Hemoglobin in Serum of Hemodialysis Patients

Ilza Salamunić / Dubravka Juretić / Dragan Ljutić
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.137


The main objective of the present study was to analyze some aspects of the function and structure of erythrocytes with respect to hemodialysis membrane biocompatibility throughout the erythrocyte and serum antioxidant levels. The study included 36 hemodialysis patients (14 female and 22 male, age 22–79 years, median 55) treated at the Department of Nephrology and Dialysis, Split Clinical Hospital in Split, and 30 control subjects matched for age and sex. Hemodialysis was performed three times a week for 4 hours with cellulose diacetate (n = 17; 6 females and 11 males) or polysulfone (n = 19; 8 females and 11 males) membranes. The aim of the study was to assess the level of oxidative stress in these patients by measuring catalytic concentrations of superoxide dismutase and glutathione peroxidase in erythrocyte lysate and scavenger systems related to free hemoglobin in serum (haptoglobin, hemopexin and bilirubin). In comparison with control values, the mean catalytic concentrations of superoxide dismutase were increased and catalytic concentrations of glutathione peroxidase decreased in patients before hemodialysis irrespective of the membrane used. Immediately after hemodialysis with either membrane, the mean catalytic concentrations of superoxide dismutase returned to the control range, while those of glutathione peroxidase were still decreased compared to control values, without any significant difference between the cellulose diacetate and polysulfone membranes. The predialysis and postdialysis values of haptoglobin, hemopexin and bilirubin in patient sera were within the range of control values. Comparison of the cellulose diacetate and polysulfone membranes showed no significant differences in the erythrocyte content of antioxidant enzymes and the scavenger system related to free hemoglobin in serum before and after hemodialysis.

About the article

Published Online: 2005-06-01

Published in Print: 2003-07-21

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 7, Pages 904–907, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.137.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

L. FENG, L.-N. TAN, Y. LIU, J. JIANG, W.-D. JIANG, K. HU, S.-H. LI, and X.-Q. ZHOU
Aquaculture Nutrition, 2011, Volume 17, Number 4, Page e875

Comments (0)

Please log in or register to comment.
Log in