Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 41, Issue 7

Issues

Endocrine Alterations in the Aging Male

Martin W. Elmlinger / Thomas Dengler / Christoph Weinstock / Werner Kuehnel
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.142

Abstract

The recent increase in the elderly population, current health trends and awareness of age-related changes in the male endocrine system, have led to discussions about the role of the hormonal changes in the aging process in males. Better prevention and treatment of suboptimal health status and age-related diseases in aging men are based on an improved understanding of aging, particularly of the significance of age-associated hormonal changes.

The aims of this study were 1) to evaluate the age dependence of the serum concentrations of the following important hormonal parameters in adult males using the IMMULITE® 1 automated assay system (DPC, Los Angeles): testosterone, dehydro-epiandrosterone sulfate (DHEAS), estradiol (E2), sex hormone binding globulin (SHBG), lutropin (LH), follitropin (FSH), cortisol, prolactin, thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4) and the growth hormone-dependent parameters insulin-like growth factor (IGF-I) and IGF-binding protein-3 (IGFBP-3) and 2) to derive the following parameters: calculated free testosterone (cFT), ratio of calculated free testosterone to total testosterone (% cFT) and free androgen index (FAI). We found a significant decrease between the 1–30-year age group and the >70-year agegroup for total testosterone (−42.4%), FAI (−65.5%), cFT (−60.0%), % cFT (−30.0%), DHEAS (−71.9%), E2 (−35.4%), TSH (−23.6%), IGF-I (−40.3%) and IGFBP-3 (−26.5%). Since the decreases in the FAI and cFT were greater than that of total testosterone and because these derived parameters reflect the biologically active fraction of testosterone, FAI and cFT are better markers for androgen deficiency in males. In contrast, a significant increase with age was observed for SHBG (+61.2%73), LH (+40.0%), FSH (+98.3%) and cortisol (+54.2%). No significant alterations with age were observed for prolactin, fT3 and fT4.

The study demonstrates that determining complete profiles of the androgenic, gonadotropic, adrenocortical, thyroid, pituitary and growth hormone/IGF endocrine axes in middle-aged and elderly men may be helpful in obtaining a correct clinical diagnosis for various hormonal disorders.

About the article

Published Online: 2005-06-01

Published in Print: 2003-07-21


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 7, Pages 934–941, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.142.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Ai Yoshihara, Jaeduk Yoshimura Noh, Hidemi Ohye, Shiori Sato, Kenichi Sekiya, Yuka Kosuga, Miho Suzuki, Masako Matsumoto, Yo Kunii, Natsuko Watanabe, Koji Mukasa, Kunihiko Ito, and Koichi Ito
Endocrine Journal, 2011, Volume 58, Number 7, Page 585
[2]
Marybeth Brown
Advances in Physiology Education, 2008, Volume 32, Number 2, Page 120
[3]
Flora Veltri, Francisco Oliveira Rocha, Dominique Willems, Jean-Philippe Praet, Lidia Grabczan, Pierre Kleynen, Thierry Pepersack, and Kris Poppe
Clinica Chimica Acta, 2017, Volume 465, Page 34
[4]
Y. R. Yan, Y. Liu, H. Huang, Q. G. Lv, X. L. Gao, J. Jiang, and N. W. Tong
QJM, 2015, Volume 108, Number 5, Page 379
[5]
Bibiana Fabre, Nahuel Fernandez Machulsky, Halina Grosman, Diego Gonzalez, Adriana Oneto, Esteban M. Repetto, Viviana Mesch, Carlos Nolazco, Osvaldo Mazza, Yori Gidron, and Gabriela Berg
Stress, 2014, Volume 17, Number 4, Page 328
[6]
J.M. Martínez Jabaloyas, A. Queipo Zaragoza, C. Ferrandis Cortes, J.A. Queipo Zaragoza, M. Gil Salom, and P. Chuan Nuez
Actas Urológicas Españolas, 2008, Volume 32, Number 6, Page 603
[7]
Ningna Li, Yaqiu Jiang, Zhongyan Shan, and Weiping Teng
British Journal of Nutrition, 2012, Volume 107, Number 05, Page 674
[8]
William E. Owen and William L. Roberts
Clinica Chimica Acta, 2005, Volume 353, Number 1-2, Page 141
[9]
Uwe Paasch, Sonja Grunewald, Juergen Kratzsch, and Hans-Juergen Glander
Fertility and Sterility, 2010, Volume 94, Number 7, Page 2898
[10]
Luboslav Stárka, Hana Pospíšilová, and Martin Hill
The Journal of Steroid Biochemistry and Molecular Biology, 2009, Volume 116, Number 1-2, Page 118
[11]
Boguslawa Baranowska, Ewa Wolinska-Witort, Wojciech Bik, Agnieszka Baranowska-Bik, Lidia Martynska, and Magdalena Chmielowska
Neurobiology of Aging, 2007, Volume 28, Number 5, Page 774
[12]
Beatriz Pérez-Cadahía, Anunciación Lafuente, Teresa Cabaleiro, Eduardo Pásaro, Josefina Méndez, and Blanca Laffon
Environment International, 2007, Volume 33, Number 2, Page 176
[13]
Journal of Anti-Aging Medicine, 2003, Volume 6, Number 3, Page 243
[14]
Henry Völzke, Dietrich Alte, Thomas Kohlmann, Jan Lüdemann, Matthias Nauck, Ulrich John, and Wieland Meng
Thyroid, 2005, Volume 15, Number 3, Page 279
[15]
ELIJAH O KEHINDE, ABAYOMI O AKANJI, ADEL AL-HUNAYAN, ANJUM MEMON, YUNUS LUQMANI, KHALEEL A AL-AWADI, RAMANI VARGHESE, ABDUL AZIZ BASHIR, and ABDALLAH S DAAR
International Journal of Urology, 2006, Volume 13, Number 4, Page 354
[16]
MICHAEL R. DESCHENES, ASHLEY N. HOLDREN, and RAYMOND W. MCCOY
Medicine & Science in Sports & Exercise, 2008, Volume 40, Number 5, Page 856
[17]
Hiren R. Modi, Surendra S. Katyare, and Minal A. Patel
Journal of Membrane Biology, 2008, Volume 221, Number 1, Page 51
[18]
E. O. Kehinde, A. O. Akanji, A. Memon, A. A. Bashir, A. S. Daar, K. A. Al-Awadi, and T. Fatinikun
International Urology and Nephrology, 2006, Volume 38, Number 1, Page 33
[19]
Alison M. Jones and John W. Honour
Clinical Endocrinology, 2006, Volume 64, Number 3, Page 234
[20]
Maria Wichers-Rother, Andreas Grigull, Piotr Sokolowski, Birgit Stoffel-Wagner, and Wolfgang Köhler
Journal of Neurology, 2005, Volume 252, Number 12, Page 1525
[21]
Elijah O. Kehinde, Abayomi O. Akanji, Olusegun A. Mojiminiyi, Khaleel A. Al-Awadi, Adel Al-Hunayan, Abdul Aziz Bashir, and Mathew P. Abraham
Medical Principles and Practice, 2005, Volume 14, Number 5, Page 342
[22]
Barbara Fuhrman, Maddalena Barba, Holger J. Schünemann, Thelma Hurd, Teresa Quattrin, Ruben Cartagena, Giuseppe Carruba, and Paola Muti
The Prostate, 2005, Volume 64, Number 2, Page 109

Comments (0)

Please log in or register to comment.
Log in