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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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ISSN
1437-4331
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Volume 41, Issue 7

Issues

Validation of an Automated Immunoturbidimetric Assay for Measurement of Plasma D-Dimer

Mojca Božič / Mojca Stegnar
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.146

Abstract

The performance characteristics and diagnostic accuracy of a new rapid automated quantitative immunoturbidimetric D-dimer assay, Auto-Dimer (Biopool, Umeå, Sweden) were evaluated in a population of 135 outpatients with suspected deep-vein thrombosis of lower limb. Enzyme-linked immunosorbent assay was used as the reference method. The Auto-Dimer assay showed good reproducibility. The correlation between Auto-Dimer and enzyme-linked immunosorbent assay was high (r = 0.91, p < 0.05) and agreement in classifying patients above or below the cut-off was good (κ coefficient 0.74, 95 % CI 0.62–0.86). At a cut-off of 340 μg/l the sensitivity and specificity of Auto-Dimer were high (100% and 61%, respectively). These data show that Auto-Dimer is a reliable screening test for exclusion of deep-vein thrombosis. The assay could be included in prospective patient management studies in order to obtain further information on its clinical usefulness.

About the article

Published Online: 2005-06-01

Published in Print: 2003-07-21


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 7, Pages 958–962, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.146.

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