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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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The Effect of Selenium on Immune Functions of J774.1 Cells

Nadia Safir / Albrecht Wendel / Rachid Saile / Layachi Chabraoui

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 8, Pages 1005–1011, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.154, June 2005

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The J774.1 macrophage cell line was used as a tool to investigate the influence of selenium on macrophage function. In vitro selenium supplementation enhanced phagocytosis, degranulation by the release of β-glucuronidase after N-formyl-methionyl-leucyl-phenylalanine (FMLP) or cytochalasin B, and the production of superoxide anion after phorbol myristate acetate stimulation of these cells, while the release of nitric oxide was not affected by the selenium status. Selenium supplementation enhanced significantly (p < 0.05) the release of tumor necrosis factor (5-fold), interleukin-1 (3-fold) and interleukin-6 (2.5-fold) after 10 μg/ml lipopolysaccharide stimulation compared to selenium-deficient cells.

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