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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

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1437-4331
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Volume 41, Issue 8

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Effects of Vitamin B12 and Folate Deficiencies on DNA Methylation and Carcinogenesis in Rat Liver

Laurent Brunaud / Jean-Marc Alberto / Ahmet Ayav / Philippe Gérard / Farès Namour / Laurent Antunes / Marc Braun / Jean-Pierre Bronowicki / Laurent Bresler / Jean-Louis Guéant
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.155

Abstract

Deficiencies of the major dietary sources of methyl groups, methionine and choline, lead to the formation of liver cancer in rodents. The most widely investigated hypothesis has been that dietary methyl insufficiency results in abnormal DNA methylation. Vitamin B12 and folate also play important roles in DNA methylation since these two coenzymes are required for the synthesis of methionine and S-adenosyl methionine, the common methyl donor required for the maintenance of methylation patterns in DNA. The aim of this study was to review the effects of methyl-deficient diets on DNA methylation and liver carcinogenesis in rats, and to evaluate the role of vitamin B12 status in defining carcinogenicity of a methyl-deficient diet. Several studies have shown that a methyl-deficient diet influences global DNA methylation. Evidence from in vivo studies has not clearly established a link between vitamin B12 and DNA methylation. We reported that vitamin B12 and low methionine synthase activity were the two determinants of DNA hypomethylation. Choline- or choline/methionine-deficient diets have been shown to cause hepatocellular carcinoma in 20–50% of animals after 12–24 months. In contrast, the effect of vitamin B12 withdrawal, in addition to choline, methionine and folate, induced hepatocellular carcinoma in less than 5% of

About the article

Published Online: 2005-06-01

Published in Print: 2003-08-07


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 8, Pages 1012–1019, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.155.

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