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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 41, Issue 9


Carbonyl Stress and Diabetic Complications

Toshio Miyata / Naoyoshi Ishikawa / Charles van Ypersele de Strihou
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2003.178


Advanced glycation irreversibly and progressively modifies proteins over time and yields the advanced glycation end-products (AGE). AGEs are thought to contribute to the development of atherosclerosis and of diabetic and uremic complications. Their inhibition has thus become a therapeutic goal. In this article, we discuss the role of various reactive carbonyl compound (RCOs) in the genesis of AGEs, postulate the existence of “carbonyl stress” in complicated diabetes and, finally, discuss therapeutic perspectives.

About the article

Published Online: 2005-06-01

Published in Print: 2003-09-16

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 41, Issue 9, Pages 1150–1158, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2003.178.

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