Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue

Issues

30,00 € / $42.00 / £23.00

Get Access to Full Text

Glyoxal and Methylglyoxal Levels in Diabetic Patients: Quantitative Determination by a New GC/MS Method

Annunziata Lapolla / Riccardo Flamini / Antonio Dalla Vedova / Antonella Senesi / Rachele Reitano / Domenico Fedele / Elisa Basso / Roberta Seraglia / Pietro Traldi

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 9, Pages 1166–1173, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.180, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Determination of glyoxal and methylglyoxal levels in plasma is of great interest, since it allows us to evaluate oxidation processes occurring in glycated proteins. A method based on a simple derivatization procedure followed by gas chromatography/mass spectrometry (GC/MS) analysis has been developed. Ten diabetic patients were evaluated before and after improvement of glycemic control. Fasting plasma glucose, hemoglobin A1c (HbA1c), advanced glycation end products (AGE), pentosidine, glyoxal and methylglyoxal levels were measured. The percentage decreases of the levels of fasting plasma glucose, HbA1c and AGE were larger than those of pentosidine, glyoxal and methylglyoxal. These results may be explained by considering the different position of these compounds in the Maillard reaction pathways: these two sets of metabolic parameters give different pictures of patients' metabolic control. The measurement of glyoxal and methylglyoxal may be particularly important in the evaluation of the possible effect of oxidative stress. Other metabolic pathways can contribute to glyoxal production, and the observed minor decrease in these compounds can be, in principle, ascribed to such effect. However, a similar behavior of pentosidine indicates that these alternative pathways can be only partially responsible for glyoxal and methylglyoxal production.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[2]
A.C. Ciobanu, T. Selescu, I. Gasler, L. Soltuzu, and A. Babes
Journal of Neuroscience Research, 2015, Page n/a
[3]
Sauradipta Banerjee, Subhajit Maity, and Abhay Sankar Chakraborti
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015
[4]
Ana Z. Penezić, Vesna B. Jovanović, Ivan D. Pavićević, Jelena M. Aćimović, and Ljuba M. Mandić
Metallomics, 2015, Volume 7, Number 10, Page 1431
[5]
Fernanda Hansen, Cíntia Eickhoff Battú, Márcio Ferreira Dutra, Fabiana Galland, Franciane Lirio, Núbia Broetto, Patrícia Nardin, and Carlos-Alberto Gonçalves
Amino Acids, 2015
[6]
V. K. Pedchenko, S. V. Chetyrkin, P. Chuang, A.-J. L. Ham, M. A. Saleem, P. W. Mathieson, B. G. Hudson, and P. A. Voziyan
Diabetes, 2005, Volume 54, Number 10, Page 2952
[7]
J. I. Barzilay, K. A. Jablonski, V. Fonseca, S. E. Shoelson, A. B. Goldfine, C. Strauch, and V. M. Monnier
Diabetes Care, 2014, Volume 37, Number 4, Page 1083
[8]
Andrea E. Tóth, András Tóth, Fruzsina R. Walter, Lóránd Kiss, Szilvia Veszelka, Béla Ózsvári, László G. Puskás, Markus M. Heimesaat, Shinya Dohgu, Yasufumi Kataoka, Gábor Rákhely, and Mária A. Deli
Archives of Medical Research, 2014, Volume 45, Number 8, Page 753
[9]
Ivan D. Pavićević, Vesna B. Jovanović, Marija M. Takić, Ana Z. Penezić, Jelena M. Aćimović, and Ljuba M. Mandić
Chemico-Biological Interactions, 2014, Volume 224, Page 42
[10]
Sidhartha K. Mahali, Neeharika Verma, and Sunil K. Manna
Journal of Cellular Physiology, 2014, Volume 229, Number 12, Page 1972
[11]
Jelena M. Aćimović, Ana Z. Penezić, Ivan D. Pavićević, Vesna B. Jovanović, and Ljuba M. Mandić
Molecular BioSystems, 2014, Volume 10, Number 8, Page 2166
[12]
Yue-Hua Wang, Yu-Pei Han, Hai-Tao Yu, Xiao-Ping Pu, and Guan-Hua Du
European Journal of Pharmacology, 2014, Volume 738, Page 374
[13]
John M.T. Chu, Dicky K.M. Lee, Daniella P.K. Wong, Ricky N.S. Wong, Ken K.L. Yung, Christopher H.K. Cheng, and Kevin K.M. Yue
Neuropharmacology, 2014, Volume 85, Page 215
[14]
Xiang Kong, Ming-zhe Ma, Kai Huang, Li Qin, Hong-mei Zhang, Zhen Yang, Xiao-yong Li, and Qing Su
Journal of Diabetes, 2014, Volume 6, Number 6, Page 535
[15]
Julie Boucher, Élie Simard, Ulrike Froehlich, and Michel Grandbois
Integr. Biol., 2014, Volume 6, Number 4, Page 411
[16]
Annika Höhn, Tobias Jung, and Tilman Grune
Free Radical Biology and Medicine, 2014, Volume 71, Page 70
[17]
James L. Figarola, Jyotsana Singhal, Samuel Rahbar, Sanjay Awasthi, and Sharad S. Singhal
Apoptosis, 2014, Volume 19, Number 5, Page 776
[18]
Sauradipta Banerjee and Abhay Sankar Chakraborti
International Journal of Biological Macromolecules, 2014, Volume 66, Page 311
[19]
A LAPOLLA, R FLAMINI, A LUPO, N C ARICÒ, C RUGIU, R REITANO, M TUBARO, E RAGAZZI, R SERAGLIA, and P TRALDI
Annals of the New York Academy of Sciences, 2005, Volume 1043, Number 1, Page 217
[20]
Yang Yang, Anuhya S Konduru, Ningren Cui, Lei Yu, Timothy C Trower, Weiwei Shi, Yun Shi, and Chun Jiang
Acta Pharmacologica Sinica, 2014, Volume 35, Number 1, Page 58
[21]
Bud-Gen Chen, Chia Han Lin, Chinpiao Chen, Boris Hambsch, and Chi-Liang Chern
Chromatographia, 2013, Volume 76, Number 9-10, Page 571
[22]
Junghyun Kim, Yun Mi Lee, Chan-Sik Kim, Eunjin Sohn, Kyuhyung Jo, So Dam Shin, and Jin Sook Kim
Journal of Diabetes Research, 2013, Volume 2013, Page 1
[23]
Miklós Péter Kalapos
Diabetes Research and Clinical Practice, 2013, Volume 99, Number 3, Page 260
[24]
Sanghamitra Chatterjee, Jiali Wen, and Aicheng Chen
Biosensors and Bioelectronics, 2013, Volume 42, Page 349
[25]
Wei Li, Ronald E. Maloney, Magdalena L. Circu, J. Steven Alexander, and Tak Yee Aw
Free Radical Biology and Medicine, 2013, Volume 54, Page 51
[27]
Sanghamitra Chatterjee and Aicheng Chen
Analytica Chimica Acta, 2012, Volume 751, Page 66
[28]
Imran Rashid, David M. van Reyk, and Michael J. Davies
FEBS Letters, 2007, Volume 581, Number 5, Page 1067
[29]
Junghyun Kim, Chan-Sik Kim, Yun Mi Lee, Kyuhyung Jo, So Dam Shin, and Jin Sook Kim
Graefe's Archive for Clinical and Experimental Ophthalmology, 2012, Volume 250, Number 5, Page 691
[30]
Jessica N. Lange, Kyle D. Wood, John Knight, Dean G. Assimos, and Ross P. Holmes
Advances in Urology, 2012, Volume 2012, Page 1
[31]
Masashi Mukohda, Muneyoshi Okada, Yukio Hara, and Hideyuki Yamawaki
Journal of Pharmacological Sciences, 2012, Volume 118, Number 3, Page 303
[32]
V. Z. Lankin, G. G. Konovalova, A. K. Tikhaze, and L. V. Nedosugova
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2012, Volume 6, Number 1, Page 81
[33]
Meng-Yan Wu, Bud-Gen Chen, Chiung Dan Chang, Mei-Han Huang, Tai-Guang Wu, Daw-Ming Chang, Yau-Jiunn Lee, Hsiang Ching Wang, Chu-I Lee, Chi-Liang Chern, and Ray H. Liu
Journal of Chromatography A, 2008, Volume 1204, Number 1, Page 81
[34]
Mathias Laga, Anneleen Cottyn, Franky Van Herreweghe, Wim Vanden Berghe, Guy Haegeman, Patrick Van Oostveldt, Joël Vandekerckhove, and Katia Vancompernolle
Biochemical Pharmacology, 2007, Volume 74, Number 4, Page 579
[35]
Nandita Shangari, Tom S. Chan, Marija Popovic, and Peter J. O’Brien
Biochemical Pharmacology, 2006, Volume 71, Number 11, Page 1610
[36]
Jelena Acimovic, Bojana Stanimirovic, and Ljuba Mandic
Journal of the Serbian Chemical Society, 2009, Volume 74, Number 8-9, Page 867
[38]
Masashi Mukohda, Tomoka Morita, Muneyoshi Okada, Yukio Hara, and Hideyuki Yamawaki
Pharmacological Research, 2012, Volume 65, Number 1, Page 91
[39]
J. Kim, E. Sohn, C.-S. Kim, and J.S. Kim
Journal of Comparative Pathology, 2011, Volume 144, Number 1, Page 41
[40]
Rasoul Nasiri, Martin J. Field, Mansour Zahedi, and Ali Akbar Moosavi-Movahedi
The Journal of Physical Chemistry A, 2011, Volume 115, Number 46, Page 13542
[41]
Annunziata Lapolla, Pietro Traldi, and Domenico Fedele
Clinical Biochemistry, 2005, Volume 38, Number 2, Page 103
[43]
Ohn Soon Kim, Junghyun Kim, Chan-Sik Kim, Nan Hee Kim, and Jin Sook Kim
Journal of Ethnopharmacology, 2010, Volume 129, Number 3, Page 285
[44]
Thomas Gawlowski, Bernd Stratmann, Alin O. Stirban, Monica Negrean, and Diethelm Tschoepe
Thrombosis Research, 2007, Volume 121, Number 1, Page 117
[45]
Junghyun Kim, Ohn Soon Kim, Chan-Sik Kim, Nan Hee Kim, and Jin Sook Kim
Chemico-Biological Interactions, 2010, Volume 188, Number 1, Page 86
[46]
Jianxin Lu, Gordon A. Zello, Edward Randell, Khosrow Adeli, John Krahn, and Qing H. Meng
Clinica Chimica Acta, 2011, Volume 412, Number 3-4, Page 286
[47]
Zdenka Turk, Maja Čavlović-Naglić, and Nikša Turk
Life Sciences, 2011, Volume 89, Number 13-14, Page 485
[48]
Tatsuya Baden, Hideyuki Yamawaki, Kazuaki Saito, Masashi Mukohda, Muneyoshi Okada, and Yukio Hara
Biochemical and Biophysical Research Communications, 2008, Volume 373, Number 2, Page 253
[49]
Hideyuki Yamawaki and Yukio Hara
Biochemical and Biophysical Research Communications, 2008, Volume 369, Number 4, Page 1155
[50]
Anunciación Espinosa-Mansilla, Isabel Durán-Merás, Florentina Cañada Cañada, and Ma Prado Márquez
Analytical Biochemistry, 2007, Volume 371, Number 1, Page 82
[51]
Fatemeh Moheimani, Joanne T. M. Tan, Bronwyn E. Brown, Alison K. Heather, David M. van Reyk, and Michael J. Davies
Experimental Diabetes Research, 2011, Volume 2011, Page 1
[52]
Seung Eun Lee, Hana Yang, Seong Il Jeong, Young-Ho Jin, Cheung-Seog Park, and Yong Seek Park
BioChip Journal, 2011, Volume 5, Number 3, Page 220
[53]
[54]
Fu-Jen Huang, Ting-Yu Chin, and Wen-Hsiung Chan
Environmental Toxicology, 2013, Volume 28, Number 8, Page 431
[55]
[56]
Elena Kostidou, George Koliakos, Konstantinos Paletas, Maria Sarigianni, and Martha Kaloyianni
The Journal of Adhesion, 2008, Volume 84, Number 12, Page 1023
[57]
[58]
C. Tatone, T. Heizenrieder, G. Di Emidio, P. Treffon, F. Amicarelli, T. Seidel, and U. Eichenlaub-Ritter
Human Reproduction, 2011, Volume 26, Number 7, Page 1843
[59]
Rukhsana Jabeen, M. Saleemuddin, John Petersen, and Amin Mohammad
Biochimie, 2007, Volume 89, Number 3, Page 311
[60]
Adriana P. Machado, Raphael S. Pinto, Zenaide P. Moysés, Edna R. Nakandakare, Eder C.R. Quintão, and Marisa Passarelli
The International Journal of Biochemistry & Cell Biology, 2006, Volume 38, Number 3, Page 392
[61]
Susana Garcia de Arriba, Ute Krügel, Ralf Regenthal, Zacharie Vissiennon, Esther Verdaguer, Anne Lewerenz, Elvira García-Jordá, Mercé Pallas, Antoni Camins, Gerald Münch, Karen Nieber, and Clemens Allgaier
Free Radical Biology and Medicine, 2006, Volume 40, Number 5, Page 779
[62]
L. F. Dmitriev and S. F. Dugin
Archives Of Physiology And Biochemistry, 2007, Volume 113, Number 2, Page 87
[63]
Masashi Mukohda, Hideyuki Yamawaki, Muneyoshi Okada, and Yukio Hara
Journal of Pharmacological Sciences, 2010, Volume 114, Number 4, Page 390
[64]
Shao-Peng Chen, Jian Wu, Xiao-Dong Yu, Jing-Juan Xu, and Hong-Yuan Chen
ELECTROPHORESIS, 2010, Volume 31, Number 18, Page 3097
[65]
O. Brouwers, P. M. Niessen, G. Haenen, T. Miyata, M. Brownlee, C. D. Stehouwer, J. G. De Mey, and C. G. Schalkwijk
Diabetologia, 2010, Volume 53, Number 5, Page 989
[66]
Paul Slusarewicz, Keng Zhu, and Tom Hedman
Journal of Materials Science: Materials in Medicine, 2010, Volume 21, Number 4, Page 1175
[67]
Masashi Mukohda, Hideyuki Yamawaki, Muneyoshi Okada, and Yukio Hara
Journal of Pharmacological Sciences, 2010, Volume 112, Number 2, Page 176
[68]
Yuri NOMI, Haruko AIZAWA, Tadao KURATA, Kazutoshi SHINDO, and Chuyen Van NGUYEN
Bioscience, Biotechnology and Biochemistry, 2009, Volume 73, Number 11, Page 2408
[69]
Sabine Kuntz, Silvia Rudloff, Julia Ehl, Reinhard G. Bretzel, and Clemens Kunz
European Journal of Nutrition, 2009, Volume 48, Number 8, Page 499
[71]
Olaf Brouwers, Tom Teerlink, Jan van Bezu, Rob Barto, Coen D.A. Stehouwer, and Casper G. Schalkwijk
Annals of the New York Academy of Sciences, 2008, Volume 1126, Number 1, Page 231
[72]
Hyun Kyoung Lee, In Ae Seo, Duk Joon Suh, Hye Jeong Lee, and Hwan Tae Park
Journal of Neurochemistry, 2009, Volume 108, Number 1, Page 273
[73]
E. Nobécourt, J. Zeng, M. J. Davies, B. E. Brown, S. Yadav, P. J. Barter, and K.-A. Rye
Diabetologia, 2008, Volume 51, Number 6, Page 1008
[74]
Jan Nicolay, Juliane Schneider, Olivier Niemoeller, Ferruh Artunc, Manuel Portero-Otin, George Haik Jr., Paul Thornalley, Erwin Schleicher, Thomas Wieder, and Florian Lang
Cellular Physiology and Biochemistry, 2006, Volume 18, Number 4-5, Page 223
[75]
Muhammad A. Mirza, Abdul J. Kandhro, Saima Q. Memon, Muhammad Y. Khuhawar, and Rafee Arain
ELECTROPHORESIS, 2007, Volume 28, Number 21, Page 3940
[76]
Yingchun Han, Edward Randell, Sudesh Vasdev, Vicki Gill, Vereesh Gadag, Leigh Anne Newhook, Marie Grant, and Donna Hagerty
Molecular and Cellular Biochemistry, 2007, Volume 305, Number 1-2, Page 123
[77]
Ahmed A. Mostafa, Edward W. Randell, Sudesh C. Vasdev, Vicki D. Gill, Yingchun Han, Vereesh Gadag, Ahmed A. Raouf, and Hala El Said
Molecular and Cellular Biochemistry, 2007, Volume 302, Number 1-2, Page 35
[78]
Nandita Shangari, Tom S. Chan, Katie Chan, Shuo Huai Wu, and Peter J. O'Brien
Molecular Nutrition & Food Research, 2007, Volume 51, Number 4, Page 445
[79]
E. Nobecourt, M. J. Davies, B. E. Brown, L. K. Curtiss, D. J. Bonnet, F. Charlton, A. S. Januszewski, A. J. Jenkins, P. J. Barter, and K.-A. Rye
Diabetologia, 2007, Volume 50, Number 3, Page 643
[80]
Ina Nemet, Lidija Varga-Defterdarović, and Zdenka Turk
Molecular Nutrition & Food Research, 2006, Volume 50, Number 12, Page 1105
[81]
Annunziata Lapolla, Domenico Fedele, Roberta Seraglia, and Pietro Traldi
Mass Spectrometry Reviews, 2006, Volume 25, Number 5, Page 775
[82]
Björn Kuhla, Hans-Joachim Lüth, Dietrich Haferburg, Michael Weick, Andreas Reichenbach, Thomas Arendt, and Gerald Münch
Journal of Neuroscience Research, 2006, Volume 83, Number 8, Page 1591
[83]
Annunziata Lapolla, Riccardo Flamini, Concetta Nadia Aricò, Carlo Rugiu, Rachele Reitano, Eugenio Ragazzi, Roberta Seraglia, Antonio Dalla Vedova, Antonio Lupo, and Pietro Traldi
Journal of Mass Spectrometry, 2006, Volume 41, Number 3, Page 405
[84]
Annunziata Lapolla, Rachele Reitano, Roberta Seraglia, Giovanni Sartore, Eugenio Ragazzi, and Pietro Traldi
Molecular Nutrition & Food Research, 2005, Volume 49, Number 7, Page 685

Comments (0)

Please log in or register to comment.