Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

See all formats and pricing


Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

Hair analysis in toxicology

Marion Villain1 / Vincent Cirimele2 / Pascal Kintz3




Corresponding author: Pascal Kintz, Laboratoire de Toxicologie, Institut de Médecine Légale, 11, rue Humann, 67000 Strasbourg, France. Phone: +33-3-90-24-33-56, Fax: +33-3-90-24-33-62, E-mail:

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 42, Issue 11, Pages 1265–1272, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2004.247, June 2005

Publication History

Published Online:


Morphological, serological and chemical examination of human hair for medical purposes was initiated some decades ago. In the 1960s and 1970s, hair analysis was used to evaluate exposure to toxic heavy metals. At this time, examination of hair for organic substances, especially drugs, was not possible because analytical methods were not sensitive enough. Since the early 1980s, the development of highly sensitive and specific assay methods such as radioimmunoassay or gas chromatography/mass spectrometry has permitted the analysis of organic substances trapped in hair. This, theoretically, offered the possibility of revealing an individual’s recent history of drug exposure beginning at sampling day and dating back over a period of weeks or months. The present review aims to summarise the various applications that have been published.

Keywords: abuse; chromatography; drugs; exposure; hair analysis; mass spectrometry; toxicology

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Małgorzata Iwona Szynkowska, Marta Marcinek, Aleksandra Pawlaczyk, and Jadwiga Albińska
Environmental Toxicology and Pharmacology, 2015
Jan C. Drooger, Agnes Jager, Mei-Ho Lam, Mathilda D. den Boer, Stefan Sleijfer, Ron H.J. Mathijssen, and Peter de Bruijn
Journal of Pharmaceutical and Biomedical Analysis, 2015, Volume 114, Page 416
Xavier Joya, Roberta Pacifici, Judith Salat-Batlle, Oscar García-Algar, and Simona Pichini
Bioanalysis, 2015, Volume 7, Number 10, Page 1273
Tooru Kamata, Noriaki Shima, Keiko Sasaki, Shuntaro Matsuta, Shiori Takei, Munehiro Katagi, Akihiro Miki, Kei Zaitsu, Toyofumi Nakanishi, Takako Sato, Koichi Suzuki, and Hitoshi Tsuchihashi
Analytical Chemistry, 2015, Volume 87, Number 11, Page 5476
Stephanie L. Stauffer, Stephanie M. Wood, and Matthew D. Krasowski
Journal of Forensic and Legal Medicine, 2015, Volume 33, Page 61
Sarah J. Ouellette, Evan Russell, Katie R. Kryski, Haroon I. Sheikh, Shiva M. Singh, Gideon Koren, and Elizabeth P. Hayden
Developmental Psychobiology, 2015, Volume 57, Number 5, Page 519
M. V. Onufriev, S. V. Freiman, T. A. Druzhkova, A. B. Guekht, and N. V. Gulyaeva
Neurochemical Journal, 2015, Volume 9, Number 1, Page 73
Phaedra Henley, Megan Lowthers, Gideon Koren, Pamela Tsimbiri Fedha, Evan Russell, Stan VanUum, Sumedha Arya, Regna Darnell, Irena F. Creed, Charles G. Trick, and John R. Bend
Canadian Journal of Physiology and Pharmacology, 2014, Volume 92, Number 9, Page 725
Man Ho Choi and Bong Chul Chung
Mass Spectrometry Reviews, 2015, Volume 34, Number 2, Page 219
Simona Pichini, Oscar Garcia-Algar, Airam Alvarez, Massimo Gottardi, Emilia Marchei, Fiorenza Svaizer, Manuela Pellegrini, Maria Rotolo, and Roberta Pacifici
International Journal of Environmental Research and Public Health, 2014, Volume 11, Number 2, Page 2288
Marta Montillo, Antonella Comin, Mirco Corazzin, Tanja Peric, Massimo Faustini, Maria Cristina Veronesi, Silvia Valentini, Marta Bustaffa, and Alberto Prandi
Journal of Equine Veterinary Science, 2014, Volume 34, Number 6, Page 774
Phaedra Henley, Zahra Jahedmotlagh, Steven Thomson, Julie Hill, Regna Darnell, Dean Jacobs, Joyce Johnson, Naomi C. Williams, Rosemary M. Williams, Stan Van Uum, John R. Bend, and Gideon Koren
Therapeutic Drug Monitoring, 2013, Volume 35, Number 5, Page 595
Tina M. Binz, Nicholas Villani, Hugo Neels, and Serge Schneider
Forensic Science International, 2012, Volume 223, Number 1-3, Page 119
Rosa Mercadante, Elisa Polledri, and Silvia Fustinoni
Analytical and Bioanalytical Chemistry, 2012, Volume 404, Number 3, Page 875
K.-W. Schramm
Chemosphere, 2008, Volume 72, Number 8, Page 1103
Reza Dahmardeh Behrooz, Mandana Barghi, Nader Bahramifar, and Abbas Esmaili-Sari
Chemosphere, 2012, Volume 86, Number 3, Page 235
Deborah A. Kennedy, Kieran Cooley, Thomas R. Einarson, and Dugald Seely
Journal of Environmental and Public Health, 2012, Volume 2012, Page 1
Loralie J. Langman and Bhushan M. Kapur
Clinical Biochemistry, 2006, Volume 39, Number 5, Page 498
Óscar García-Algar, María Ángeles López-Vílchez, Roberta Pacifici, and Simona Pichini
Medicina Clínica, 2005, Volume 125, Number 11, Page 436
Nicolaas H. Fourie and Robin M. Bernstein
General and Comparative Endocrinology, 2011, Volume 174, Number 2, Page 150
R. de la Torre, E. Civit, F. Svaizer, A. Lotti, M. Gottardi, and M. Miozzo
Forensic Science International, 2010, Volume 196, Number 1-3, Page 18
Manuela Pellegrini, Adriana Casá, Emilia Marchei, Roberta Pacifici, Ruth Mayné, Vanessa Barbero, Oscar Garcia-Algar, and Simona Pichini
Journal of Pharmaceutical and Biomedical Analysis, 2006, Volume 40, Number 3, Page 662
Daniel Krewski, Robert A Yokel, Evert Nieboer, David Borchelt, Joshua Cohen, Jean Harry, Sam Kacew, Joan Lindsay, Amal M Mahfouz, and Virginie Rondeau
Journal of Toxicology and Environmental Health, Part B, 2007, Volume 10, Number sup1, Page 1
Hyun-Jin Jung, Sun Ju Kim, Won-Yong Lee, Bong Chul Chung, and Man Ho Choi
Rapid Communications in Mass Spectrometry, 2011, Volume 25, Number 9, Page 1184
S. Boyer, P. Garcia, M.A. Popot, V. Steiner, and M. Lesieur
Journal of Chromatography B, 2007, Volume 852, Number 1-2, Page 684
Francesca Bucelli, Angela Fratini, Paolo Bavazzano, and Nicola Comodo
Journal of Chromatography B, 2009, Volume 877, Number 31, Page 3931
Marilyn A. Huestis and Michael L. Smith
Drug Discovery Today: Technologies, 2006, Volume 3, Number 1, Page 49
Renata Wietecha-Posłuszny, Aneta Garbacik, Michał Woźniakiewicz, and Paweł Kościelniak
Analytical and Bioanalytical Chemistry, 2011, Volume 399, Number 9, Page 3233
Idil Bozkus, Derya Germec-Cakan, and Tulin Arun
Journal of Craniofacial Surgery, 2011, Volume 22, Number 1, Page 68
Emilia Marchei, Abhilasha Durgbanshi, Silvia Rossi, Óscar Garcia-Algar, Piergiorgio Zuccaro, and Simona Pichini
Rapid Communications in Mass Spectrometry, 2005, Volume 19, Number 22, Page 3416

Comments (0)

Please log in or register to comment.