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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Volume 42, Issue 11 (Nov 2004)


Hair analysis in toxicology

Marion Villain / Vincent Cirimele
  • Laboratoire de Toxicologie, Institut de Médecine Légale, Strasbourg and Laboratoire ChemTox, Rue Geiler de Kaysersberg, Illkirch, France
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Pascal Kintz
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2004.247


Morphological, serological and chemical examination of human hair for medical purposes was initiated some decades ago. In the 1960s and 1970s, hair analysis was used to evaluate exposure to toxic heavy metals. At this time, examination of hair for organic substances, especially drugs, was not possible because analytical methods were not sensitive enough. Since the early 1980s, the development of highly sensitive and specific assay methods such as radioimmunoassay or gas chromatography/mass spectrometry has permitted the analysis of organic substances trapped in hair. This, theoretically, offered the possibility of revealing an individual’s recent history of drug exposure beginning at sampling day and dating back over a period of weeks or months. The present review aims to summarise the various applications that have been published.

Keywords: abuse; chromatography; drugs; exposure; hair analysis; mass spectrometry; toxicology


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About the article

Corresponding author: Pascal Kintz, Laboratoire de Toxicologie, Institut de Médecine Légale, 11, rue Humann, 67000 Strasbourg, France. Phone: +33-3-90-24-33-56, Fax: +33-3-90-24-33-62, E-mail:

Published Online: 2005-06-01

Published in Print: 2004-11-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2004.247.

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