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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Volume 42, Issue 12 (Dec 2004)


Declines in serum free and bound choline concentrations in humans after three different types of major surgery

Yesim Ozarda Ilcol
  • Department of Biochemistry and Clinical Biochemistry, Uludag University Medical School, Bursa, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gurkan Uncu / Suna Goren
  • Department of Anesthesiology and Reanimation, Uludag University Medical School, Bursa, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Erkan Sayan
  • Department of Anesthesiology and Reanimation, Uludag University Medical School, Bursa, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ismail H. Ulus
  • Department of Pharmacology and Clinical Pharmacology, Uludag University Medical School, Bursa, Turkey
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2004.259


We examined the changes in circulating choline status in humans in response to major surgery by measuring serum free and phospholipid-bound choline concentrations before, during and 1–72h after total abdominal hysterectomy, off-pump coronary artery graft surgery or brain tumor surgery. Preoperatively, the mean serum free and phospholipid-bound choline concentrations in patients scheduled for abdominal hysterectomy (n=26), off-pump coronary artery grafting surgery (n=34) or brain tumor surgery (n=24) were 12.3±0.5, 12.1±0.4 and 11.4±0.4μmol/l, and 2495±75, 2590±115 and 2625±80μmol/l, respectively. Serum free choline and phospholipid-bound choline concentrations decreased from these baseline values to 8.8±0.7 (p<0.001), 8.8±0.5 (p<0.001) and 8.2±0.4μmol/l (p<0.001), and 2050±108 (p<0.001), 2166±59 (p<0.001) and 1884±104μmol/l (p<0.001) at 1h after hysterectomy, off-pump bypass graft surgery or brain tumor surgery, respectively. They remained at these low levels for 24h and then gradually increased towards the preoperative values at 48–72h postoperatively. Serum cortisol increased postoperatively in all surgical patients for 24h and its levels were inversely correlated with serum free and bound choline concentrations. These results show that circulating free and bound choline concentrations decrease for 72h after total abdominal hysterectomy, off-pump coronary artery graft surgery or brain tumor surgery in humans.

Keywords: bound choline; brain surgery; cortisol; free choline; hysterectomy; surgical stress


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About the article

Corresponding author: Doc. Dr. Yesim Ozarda IIcol, Uludag University Medical School, Department of Biochemistry and Clinical Biochemistry, 16059 Bursa, Turkey Phone: +90-224-4428083, Fax: +90-224-4428083,

Received: 2004-07-20

Accepted: 2004-09-15

Published Online: 2005-06-01

Published in Print: 2004-12-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2004.259.

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