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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

Online
ISSN
1437-4331
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Volume 42, Issue 2 (Feb 2004)

Issues

Immunoglobulin G Fcγ receptor expression on polymorphonuclear cells in bronchoalveolar lavage fluid of HIV-infected and HIV-seronegative patients with bacterial pneumonia

Christine Armbruster / Walter Krugluger / Monika Huber / Stephan Kriwanek
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2004.035

Abstract

This study was designed to test the hypothesis that impaired neutrophil function might contribute to the development of bacterial pneumonia in patients with HIV-infection. Numbers of inflammatory cells and immunoglobulin G Fcγ receptor (IgG FcγR) I, II, III levels were investigated in bronchoalveolar lavage (BAL) fluid of HIV-seronegative and HIV-infected patients with bacterial pneumonia. The 99 patients were classified into three groups: I: HIV-seronegative and pneumonia (n=40); II: HIV-infected and pneumonia (n=19); III: HIV-seronegative with other pulmonary diseases than pneumonia (n=40). The results of groups I and II, II and III, and I and III were compared. The percentage of alveolar macrophages was significantly lower (group II vs. III: p=0.005, group I vs. III: p=0.001), that of neutrophils increased significantly in patients with pneumonia (group II vs. III: p=0.02, group I vs. III: p=0.01). Lymphocytes differed only between groups I and III (p=0.04). Although only the expression of FcγRI was significantly higher in HIV-seronegative pneumonia patients compared to those without pneumonia (p=0.01), the mean expression of all three receptors was lower in the HIV-infected group, with that of FcγRI approaching statistical significance.

This report provides first evidence that altered FcγR expression on BAL neutrophils might contribute to the increased susceptibility of HIV-infected patients to bacterial pneumonia.

About the article

Published Online: 2005-06-01

Published in Print: 2004-02-18


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2004.035. Export Citation

Citing Articles

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[1]
James M. Beck
Clinics in Chest Medicine, 2013, Volume 34, Number 2, Page 143

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