Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 42, Issue 4


The influence of smoking on plasma homocysteine and cysteine levels in passive and active smokers

Andrzej Sobczak / Wladyslaw Wardas / Wioleta Zielinska-Danch / Krzysztof Pawlicki
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2004.072


Total plasma homocysteine (tHcy) and cysteine (tCys) levels are associated with cardiovascular diseases. One of the determinants that influence their levels is cigarette smoking. The aim of this study was to determine the relationship between plasma levels of both amino acids and urinary cotinine concentration as a reliable biomarker of tobacco smoke exposure. One hundred and seventeen volunteers (61 women and 56 men) aged 19–60 years (mean 40.3±11.0) were included in the study. The study subjects were qualified into non-smokers, passive smokers and active smokers based upon the urinary cotinine concentration. In each particular group, plasma tHcy and tCys levels were measured and evaluated in the whole population and separately in women and men. Statistically insignificant differences in plasma tHcy and tCys levels in the whole group of passive smokers in comparison with non-smokers were observed (11.47 vs. 10.94 μmol/l, p=0.414, and 253.0 vs. 266.9 μmol/l, p=0.163, respectively). However, statistically significant differences in plasma tHcy levels (13.29 vs. 10.94 μmol/l, p=0.011) and in plasma tCys levels (218.2 vs. 266.9 μmol/l, p<0.001) were found in the whole group of active smokers compared with nonsmokers. The Pearson's coefficient (r) for the correlation between plasma tHcy level and urinary cotinine concentration was r=0.630 (p<0.001) in the whole group of active smokers and r=0.480 (p=0.003) in the whole group of passive smokers. The correlation between plasma tCys level and urinary cotinine concentration in both study groups was insignificant. Similar results were obtained when calculated separately for men and women. The results suggest that cigarette smoking is a strong determinant of plasma tHcy level, but it is not a determinant of plasma tCys level.

About the article

Published Online: 2005-06-01

Published in Print: 2004-04-05

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 42, Issue 4, Pages 408–414, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2004.072.

Export Citation

Copyright © 2004 by Walter de Gruyter GmbH & Co. KG.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Aleš Linhart and Michael Aschermann
Cor et Vasa, 2011, Volume 53, Number 4-5, Page 253
William H. Frishman
Therapeutic Advances in Cardiovascular Disease, 2009, Volume 3, Number 4, Page 287
A. Feliciano, M.J. Oliveira, A. Cysneiros, C. Martinho, R.P. Reis, D. Penque, P. Pinto, and C. Bárbara
Revista Portuguesa de Pneumologia (English Edition), 2017, Volume 23, Number 4, Page 193
Fatima Cintra
Chest, 2011, Volume 140, Number 1, Page 268
Ute Mons, Joshua E. Muscat, Jennifer Modesto, John P. Richie, and Hermann Brenner
Free Radical Biology and Medicine, 2016, Volume 91, Page 172
Fabrizia Bamonti, Marco Pellegatta, Cristina Novembrino, Luisella Vigna, Rachele De Giuseppe, Federica de Liso, Dario Gregori, Cinzia Della Noce, Lorenzo Patrini, Gianfranco Schiraldi, Paola Bonara, Laura Calvelli, Rita Maiavacca, and Giuliana Cighetti
Journal of the American College of Nutrition, 2013, Volume 32, Number 1, Page 18
Abdulbaki Karaoglu, Turan Tunc, Gokhan Aydemir, Onder Onguru, Bulent Uysal, Mustafa Kul, Secil Aydinoz, Emin Oztas, and Umit Sarici
Fetal and Pediatric Pathology, 2012, Volume 31, Number 6, Page 432
H. Gourlain and M. Galliot-Guilley
Journal de Gynécologie Obstétrique et Biologie de la Reproduction, 2005, Volume 34, Page 154
Gerhard Scherer
Experimental and Toxicologic Pathology, 2005, Volume 57, Page 75
B.J. Jefferis, G.D.O. Lowe, P. Welsh, A. Rumley, D.A. Lawlor, S. Ebrahim, C. Carson, M. Doig, C. Feyerabend, L. McMeekin, S.G. Wannamethee, D.G. Cook, and P.H. Whincup
Atherosclerosis, 2010, Volume 208, Number 2, Page 550
Rajinder K. Dhamija, P. Gaba, S. Arora, A. Kaintura, M. Kumar, and J. Bhattacharjee
Journal of the Neurological Sciences, 2009, Volume 281, Number 1-2, Page 64
Mili Gupta, Priyanka Sharma, Gitanjali Garg, Kiranjeet Kaur, Gurdeep Kaur Bedi, and Anil Vij
Clinica Chimica Acta, 2005, Volume 352, Number 1-2, Page 121
Isil Coker, Ayfer Colak, Aybike Gunaslan Hasturk, Omur Yildiz, Hakan Turkon, and Oya Halicioglu
Gynecologic and Obstetric Investigation, 2011, Volume 71, Number 4, Page 245
M. Baines, M.-B. Kredan, J. Usher, A. Davison, G. Higgins, W. Taylor, C. West, W.D. Fraser, and L.R. Ranganath
Bone, 2007, Volume 40, Number 3, Page 730
Osvaldo P. Almeida and Jon J. Pfaff
Journal of Affective Disorders, 2005, Volume 86, Number 2-3, Page 317
Yeong-Chul Park, Min-Hee Kim, and Jong-Bong Kim
Toxicological Research, 2007, Volume 23, Number 4, Page 311
Carlos Campos, Rodrigo Guzmán, Encarnación López-Fernández, and Ángela Casado
Inhalation Toxicology, 2011, Volume 23, Number 3, Page 148
Maurizio Minetti, Thomas L. Leto, and Walter Malorni
Antioxidants & Redox Signaling, 2008, Volume 10, Number 4, Page 829
Rosa Chillemi, Jacques Simpore, Silvia Persichilli, Angelo Minucci, Alfonsina D'Agata, and Salvatore Musumeci
Clinical Chemistry and Laboratory Medicine (CCLM), 2005, Volume 43, Number 7
Sivaramapanicker Sreejith, Kizhumuri P. Divya, and Ayyappanpillai Ajayaghosh
Angewandte Chemie, 2008, Volume 120, Number 41, Page 8001
Sivaramapanicker Sreejith, Kizhumuri P. Divya, and Ayyappanpillai Ajayaghosh
Angewandte Chemie International Edition, 2008, Volume 47, Number 41, Page 7883
M. Baines, M.-B. Kredan, A. Davison, G. Higgins, C. West, W. D. Fraser, and L. R. Ranganath
Calcified Tissue International, 2007, Volume 81, Number 6, Page 450
William H. Frishman
Preventive Cardiology, 2007, Volume 10, Number s2, Page 10

Comments (0)

Please log in or register to comment.
Log in