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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
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Volume 42, Issue 5 (May 2004)

Issues

Genetic analysis of glutathione S-transferase A1 and T1 polymorphisms in a Japanese population

Kumi Matsuno / Takahiro Kubota / Yuji Matsukura / Hiroshi Ishikawa / Tatsuji Iga
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2004.095

Abstract

Novel allelic variants have been found in the glutathione S-transferase (GST) A1 and T1 genes. The former GSTA1*B allele is associated with low expression and the latter GSTT1*B allele lacks GSTT1 activity. The information on frequencies of both variants is poorly documented in the Japanese population. In this study we determined the frequencies of allelic variants of GSTA1 and GSTT1 in a Japanese population using PCR-restriction fragment length polymorphism and allele-specific PCR. The frequencies of GSTA1*B, GSTT1*0 and GSTT1*B alleles in the subjects were 16.0%, 71.1% and 0%, respectively. This is the first report on the frequencies of allelic variants of GSTA1 and GSTT1 in a Japanese population.

About the article

Published Online: 2005-06-01

Published in Print: 2004-05-10


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2004.095.

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Copyright © 2004 by Walter de Gruyter GmbH & Co. KG. Copyright Clearance Center

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