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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Proposal for guidelines to establish common biological reference intervals in large geographical areas for biochemical quantities measured frequently in serum and plasma

Pål Rustad / Peter Felding / Ari Lahti
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2004.131


A suggestion for a standard procedure to establish biological reference intervals for biochemical quantities by a multicenter approach is presented. This procedure was developed for and used in the Nordic Reference Interval Project 2000 (NORIP). This project established biological reference intervals for 25 frequently requested biochemical quantities through cooperation of 102 Nordic laboratories. Each laboratory performed collection of reference samples and measurement using their routine methods. The bias of each routine method was eliminated by use of common reference materials measured in each of the participating laboratories.

Published Online: 2005-06-01

Published in Print: 2004-07-05

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 42, Issue 7, Pages 783–791, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2004.131, June 2005

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