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Volume 43, Issue 10 (Oct 2005)


Molecular targeting by homocysteine: a mechanism for vascular pathogenesis

Donald W. Jacobsen
  • Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, United States of America
/ Otilia Catanescu
  • Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States of America
/ Patricia M. DiBello
  • Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States of America
/ John C. Barbato
  • Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States of America
Published Online: 2011-09-21 | DOI: https://doi.org/10.1515/CCLM.2005.188


Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Although there is a growing body of evidence that homocysteine plays a causal role in atherogenesis, specific mechanisms to explain the underlying pathology have remained elusive. This review focuses on chemistry unique to the homocysteine molecule to explain its inherent cytotoxicity. Thus, the high pKa of the sulfhydryl group (pKa=10.0) of homocysteine underlies its ability to form stable disulfide bonds with protein cysteine residues, and in the process, alters or impairs the function of the protein. Albumin, fibronectin, transthyretin, annexin II, and factor V have now been identified as molecular targets for homocysteine, and in the case of albumin, the mechanism of targeting has been elucidated.

Keywords: albumin; atherogenesis; disulfide bond; glutathione peroxidase; homocysteine; hyperhomocysteinemia; molecular targeting; pKa; sulfhydryl group; vascular pathogenesis


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About the article

Corresponding author: Donald W. Jacobsen, PhD, Department of Cell Biology, NC-10, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA Phone: +1-216-444-8340, Fax: +1-216-445-5480,

Published Online: 2011-09-21

Published in Print: 2005-10-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2005.188. Export Citation

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