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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Online
ISSN
1437-4331
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Volume 43, Issue 10 (Oct 2005)

Issues

Plasma homocysteine levels in L-dopa-treated Parkinson's disease patients with cognitive dysfunctions

Stefano Zoccolella
  • Department of Neurological Sciences, University of Bari, Bari, Italy
/ Paolo Lamberti
  • Department of Neurological Sciences, University of Bari, Bari, Italy
/ Giovanni Iliceto
  • Department of Neurological Sciences, University of Bari, Bari, Italy
/ Cosimo Diroma
  • Department of Neurological Sciences, University of Bari, Bari, Italy
/ Elio Armenise
  • Department of Internal Medicine and Public Health, Hygiene Section, University of Bari, Bari, Italy
/ Giovanni Defazio
  • Department of Neurological Sciences, University of Bari, Bari, Italy
/ Simona V. Lamberti
  • Department of Neurological Sciences, University of Bari, Bari, Italy
/ Angela Fraddosio
  • Department of Neurological Sciences, University of Bari, Bari, Italy
/ Michele de Mari
  • Department of Neurological Sciences, University of Bari, Bari, Italy
/ Paolo Livrea
  • Department of Neurological Sciences, University of Bari, Bari, Italy

Abstract

Elevated plasma homocysteine (Hcy) concentrations are associated with Alzheimer's disease and vascular dementia. Several recent reports have indicated that L-dopa treatment is an acquired cause of hyperhomo-cysteinemia. Despite the fact that a large proportion of Parkinson's disease (PD) patients develop cognitive dysfunctions or dementia, particularly in the late stages of the illness and after long-term L-dopa treatment, the relationship between Hcy and dementia in PD has not been fully investigated. The aim of this study was to evaluate plasma Hcy levels in a group of L-dopa-treated PD patients with cognitive impairment and to elucidate a possible role of Hcy in the development of cognitive dysfunctions in PD. We compared Hcy, vitamin B12 and folate levels in 35 parkinsonian patients treated with L-dopa (14 with cognitive dysfunctions, 21 without cognitive impairment). Analysis of the data revealed that mean Hcy levels were significantly higher in the group with cognitive dysfunctions (21.2±7.4 vs. 15.8±4.4 μmol/L; p=0.0001), while there was no difference in age, sex, B12 and folate levels. In addition, logistic regression analysis showed that the risk of cognitive dysfunction progressively increased according to Hcy levels after correction for age, sex and B-vitamin status (odds ratio, 19.1; 95% CI, 1.5–241.4; p=0.02). Our results raise the possibility of a relationship between Hcy levels and cognitive dysfunctions in this group of L-dopa-treated PD patients. However, prospective studies on large cohorts of patients should be performed to clarify such an association.

Keywords: cognitive dysfunctions; dementia; homocysteine, L-dopa; Parkinson's disease

References

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About the article

Corresponding author: Prof. Paolo Lamberti, Department of Neurological Sciences, University of Bari, Ospedale Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy Phone: +39-0805592321, Fax: +39-0805478532,


Published in Print: 2005-10-01


Citation Information: Clinical Chemical Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2005.193. Export Citation

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