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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

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Volume 43, Issue 12 (Dec 2005)

Issues

Protein microarrays for the diagnosis of allergic diseases: state-of-the-art and future development

Christian Harwanegg
  • VBC Genomics Bioscience Research LLC, Vienna, Austria
/ Reinhard Hiller
  • VBC Genomics Bioscience Research LLC, Vienna, Austria
Published Online: 2005-11-28 | DOI: https://doi.org/10.1515/CCLM.2005.226

Abstract

In the emerging field of Functional Proteomics, protein microarrays are considered to be one of the most promising tools for the simultaneous analysis of the a) abundance, b) function, and c) interaction of proteins on a system-wide scale. Resting on the technological grounds of widely used DNA biochips, the great power of microarray-based miniature solid-phase immunoassays lies in their potential to investigate in parallel large numbers of analyte pairs in a variety of biological samples. Consequently, this has fuelled aspirations that protein microarrays may serve as tools for the high-throughput functional investigation of complete proteomes and, moreover, that they will develop into promising candidates for innovative in-vitro diagnostic (IVD) applications. To date, published examples of protein microarrays for IVD purposes have included tests for allergy, autoimmune and infectious diseases. Here, we discuss recent advancements in the development of protein microarrays for the profiling of IgE antibodies in the diagnosis of Type 1-related allergic diseases.

Keywords: allergy; biochip; component resolved diagnosis; IgE; microarray; molecular diagnostics; recombinant allergen

References

  • 1.

    Pollack JR, Iyer VR. Characterizing the physical genome. Nat Genet 2002; 32:515–21.CrossrefGoogle Scholar

  • 2.

    de Leon J, Susce MT, Pan RM, Fairchild M, Koch WH, Wedlund PJ. The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation. J Clin Psychiatry 2005; 66:15–27.CrossrefGoogle Scholar

  • 3.

    Gygi SP, Rochon Y, Franza BR, Aebersold R. Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 1999; 19:1720–30.CrossrefGoogle Scholar

  • 4.

    Zhu H, Snyder M. Protein chip technology. Curr Opin Chem Biol 2003; 7:55–63.CrossrefGoogle Scholar

  • 5.

    Stoll D, Templin MF, Bachmann J, Joos TO. Protein microarrays: applications and future challenges. Curr Opin Drug Discov Devel 2005; 8:239–52.Google Scholar

  • 6.

    Ekins R, Chu F, Biggart E. Multispot, multianalyte immunoassay. Ann Biol Clin 1990; 48:655–66.Google Scholar

  • 7.

    Labaer J, Ramachandran N. Protein microarrays as tools for functional proteomics. Curr Opin Chem Biol 2005; 9:14–9.CrossrefGoogle Scholar

  • 8.

    Gokler J, Angenendt P. Protein and antibody microarray technology. J Chromatogr B Analyt Technol Biomed Life Sci 2003; 797:229–40.CrossrefGoogle Scholar

  • 9.

    Sennhauser FH, Braun-Fahrlander C, Wildhaber JH. The burden of asthma in children: a European perspective. Paediatr Respir Rev 2005; 6:2–7.CrossrefGoogle Scholar

  • 10.

    Johansson SGO, Bennich H, Wide L. A new class of immunoglobulin in human serum. Immunology 1968; 14:265–72.Google Scholar

  • 11.

    Wide L, Bennich H, Johannson SGO. Diagnosis of allergy by an in-vitro test for allergen antibodies. Lancet 1967; 2:1105–7.CrossrefGoogle Scholar

  • 12.

    van Ree R; CREATE Partnership. The CREATE project: EU support for the improvement of allergen standardization in Europe. Allergy 2004; 59:571–4.Google Scholar

  • 13.

    Kazemi-Shirazi L, Niederberger V, Linhart B, Lidholm J, Kraft D, Valenta R. Recombinant marker allergens: diagnostic gatekeepers for the treatment of allergy. Int Arch Allergy Immunol 2002; 127:259–68.CrossrefGoogle Scholar

  • 14.

    Chapman MD, Smith AM, Vailes LD, Arruda LK, Dhanaraj V, Pomes A. Recombinant allergens for diagnosis and therapy of allergic disease. J Allergy Clin Immunol 2000; 106:409–18.CrossrefGoogle Scholar

  • 15.

    Thomas WR, Smith W. Towards defining the full spectrum of important house dust mite allergens. Clin Exp Allergy 1999; 29:1583–7.CrossrefGoogle Scholar

  • 16.

    Niederberger V, Horak F, Vrtala S, Spitzauer S, Krauth MT, Valent P, et al. Vaccination with genetically engineered allergens prevents progression of allergic disease. Proc Natl Acad Sci USA 2004; 101(Suppl 2):14677–82.Google Scholar

  • 17.

    Valenta R, Lidholm J, Niederberger V, Hayek B, Kraft D, Gronlund H. The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT). Clin Exp Allergy 1999; 29:896–904.CrossrefGoogle Scholar

  • 18.

    Schmid-Grendelmeier P, Holzmann D, Himly M, Weichel M, Tresch S, Ruckert B, et al. Native Art v 1 and recombinant Art v 1 are able to induce humoral and T cell-mediated in vitro and in vivo responses in mugwort allergy. J Allergy Clin Immunol 2003; 111:1328–36.Google Scholar

  • 19.

    Deinhofer K, Sevcik H, Balic N, Harwanegg C, Hiller R, Rumpold H, et al. Microarrayed allergens for IgE profiling. Methods 2004; 32:249–54.CrossrefGoogle Scholar

  • 20.

    Harwanegg C, Spitzauer S, Valenta R, Mueller MW, Hiller R. Protein biochips for the profiling of allergen-specific antibodies. In: Mark Schena, editor. Protein microarrays. Sudbury, MA (USA): Jones and Bartlett 2004, Chapter 13.Google Scholar

  • 21.

    Hantusch B, Scholl I, Harwanegg C, Krieger S, Becker WM, Spitzauer S, et al. Affinity determinations of purified IgE and IgG antibodies against the major pollen allergens Phl p 5a and Bet v 1a: discrepancy between IgE and IgG binding strength. Immunol Lett 2005; 97:81–9.CrossrefGoogle Scholar

  • 22.

    Harwanegg C, Laffer S, Hiller R, Mueller MW, Kraft D, Spitzauer S, et al. Microarrayed recombinant allergens for diagnosis of allergy. Clin Exp Allergy 2003; 33:7–13.CrossrefGoogle Scholar

  • 23.

    Mullenix MC, Wiltshire S, Shao W, Kitos G, Schweitzer B. Allergen-specific IgE detection on microarrays using rolling circle amplification: correlation with in vitro assays for serum IgE. Clin Chem 2001; 47:1926–9.Google Scholar

  • 24.

    Wiltshire S, O'Malley S, Lambert J, Kukanskis K, Edgar D, Kingsmore SF, et al. Detection of multiple allergen-specific IgEs on microarrays by immunoassay with rolling circle amplification. Clin Chem 2000; 46:1990–3.Google Scholar

  • 25.

    Kim TE, Park SW, Cho NY, Choi SY, Yong TS, Nahm BH, et al. Quantitative measurement of serum allergen-specific IgE on protein chip. Exp Mol Med 2002; 34:152–8.CrossrefGoogle Scholar

  • 26.

    Hiller R, Laffer S, Harwanegg C, Huber M, Schmidt WM, Twardosz A, et al. Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J 2002; 16:414–6.Google Scholar

  • 27.

    Jahn-Schmid B, Harwanegg C, Hiller R, Bohle B, Ebner C, Scheiner O, et al. Allergen microarray: comparison of microarray using recombinant allergens with conventional diagnostic methods to detect allergen-specific serum immunoglobulin E. Clin Exp Allergy 2003; 33:1443–9.CrossrefGoogle Scholar

About the article

Corresponding author: Reinhard Hiller, VBC-GENOMICS Bioscience Research LLC, Rennweg 95 B, 1030 Vienna, Austria Phone: +43 1 796 65 72-51, Fax: +43 1 796 65 72-320,


Published Online: 2005-11-28

Published in Print: 2005-12-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2005.226.

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[9]
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[11]
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[12]
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[13]
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