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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

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Volume 43, Issue 3


Soluble transferrin receptor and transferrin receptor-ferritin index in iron deficiency anemia and anemia in rheumatoid arthritis

Sandra Margetic / Elizabeta Topic / Dragica Ferenec Ruzic / Marina Kvaternik
Published Online: 2014-06-05 | DOI: https://doi.org/10.1515/CCLM.2005.056


The aim of the study was to evaluate the clinical efficiency of soluble transferrin receptor and transferrin receptor-ferritin index (sTfR/logF) in the diagnosis of iron deficiency anemia, as well as the differential diagnosis of iron deficiency anemia and anemia in rheumatoid arthritis. The study included 96 patients with anemia and 61 healthy volunteers as a control group. In healthy subjects there were no significant sex and age differences in the parameters tested. The study results showed these parameters to be reliable in the diagnosis of iron deficiency anemia, as well as in the differential diagnosis of iron deficiency anemia and anemia of chronic disease. The results indicate that sTfR/logF could be used to help differentiate coexisting iron deficiency in patients with anemia of chronic disease. Receiver operating characteristic analysis showed a higher discriminating power of transferrin receptor-ferritin index vs. soluble transferrin receptor in the diagnosis of iron deficiency anemia, as well as in the differential diagnosis between iron deficiency anemia and anemia of chronic disease. In patients with anemia in rheumatoid arthritis, the parameters tested showed no significant differences with respect to C-reactive protein concentration. These results suggested that the parameters tested are not affected by acute or chronic inflammatory disease.

Keywords: anemia in rheumatoid arthritis; iron deficiency anemia; soluble transferrin receptor; transferrin receptor-ferritin index


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About the article

Corresponding author: Sandra Margetic, Department of Hematology, Clinical Institute of Chemistry, Sestre milosrdnice University Hospital, Vinogradska c. 29, 10 000 Zagreb, Croatia Phone: +385-1-3787-436, Phone/fax: +385-1-3768-280,

Received: 2004-07-23

Accepted: 2005-01-18

Published Online: 2014-06-05

Published in Print: 2005-03-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 43, Issue 3, Pages 326–331, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2005.056.

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