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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1437-4331
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Volume 43, Issue 4

Issues

Evaluation of a rapid bedside test for the quantitative determination of C-reactive protein

Susanna Esposito
  • Institute of Pediatrics, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena”, University of Milan, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Elena Tremolati
  • Institute of Pediatrics, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena”, University of Milan, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Enrica Begliatti
  • Institute of Pediatrics, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena”, University of Milan, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Samantha Bosis
  • Institute of Pediatrics, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena”, University of Milan, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Laura Gualtieri
  • Institute of Pediatrics, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena”, University of Milan, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nicola Principi
  • Institute of Pediatrics, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena”, University of Milan, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-09-21 | DOI: https://doi.org/10.1515/CCLM.2005.077

Abstract

Regardless of its origin, any condition associated with inflammation is accompanied by an increase in serum C-reactive protein levels. This study compared the results of a rapid test for the bedside assay of C-reactive protein (QuikRead CRP, Orion Corporation, Orion Diagnostica, Espoo, Finland) with those of a standard laboratory assay in samples taken from 231 children aged less than 14years (126 males; median age 4.7years) attending the Emergency Department of Milan University's Institute of Pediatrics because of acute respiratory infection. The two methods showed similar median C-reactive protein levels (standard laboratory assay: 34.7mg/L, range 4–199mg/L; QuikRead CRP: 33.3mg/L, range <8–196mg/L; p=0.779) and a similar distribution of children with C-reactive protein levels of <20mg/L, 20–70mg/L and >70mg/L. This study shows for the first time that the rapid QuikRead CRP test can be performed at the bedside or in an outpatient clinic and, in less than 5min, gives the same quantitative results as those obtained using a more complex routine laboratory method.

Keywords: acute phase response; children; markers of infection; rapid tests; C-reactive protein

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About the article

Corresponding author: Susanna Esposito, Institute of Pediatrics, Fondazione IRCCS “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena”, University of Milan, Via Commenda 9, 20122 Milano, Italy Phone: +39-02-57992498, Fax: +39-02-50320226,


Received: 2004-12-27

Accepted: 2005-02-11

Published Online: 2011-09-21

Published in Print: 2005-04-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 43, Issue 4, Pages 438–440, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2005.077.

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