Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

See all formats and pricing


Select Volume and Issue
Loading journal volume and issue information...

Comparison of iodine contents in gastric cancer and surrounding normal tissues

Mine Gulaboglu1 / Leyla Yildiz2 / Fehmi Celebi3 / Mustafa Gul4 / Kemal Peker5






Corresponding author: Mine Gulaboglu, PhD, Department of Biochemistry, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey Phone: +90-442-2360961, Fax: +90-442-2360962,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 43, Issue 6, Pages 581–584, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2005.101, July 2005

Publication History

January 11, 2005
April 1, 2005
Published Online:


It has been suggested that iodine plays an important role in gastric cancer. Gastric cancer ranks first among the cancers in the north-eastern Anatolia region, Turkey, where iodine deficiency is common. In this study, iodine levels were determined in gastric cancer and surrounding normal tissues in 19 patients with gastric cancer. Tissue iodine levels were determined by the Foss method based on the Sandell-Kolt-hoff reaction. Tissue iodine levels were lower in gastric cancer tissue (17.8±3.4 ng I/mg protein, mean±SEM) compared with surrounding normal tissue (41.7±8.0 ng I/mg protein) (p<0.001). There was positive correlation between the iodine levels in gastric cancer tissue and surrounding normal tissue (r=0.845, p<0.001). There was no significant difference in iodine levels in cancer and surrounding normal tissue between male and female subjects. The iodine deficiency in our region may be one of the factors for increased gastric cancer prevalence. Our results support the hypothesis that iodine plays an important role in gastric cancer development.

Keywords: gastric cancer; iodine; tissue.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Mohammad Tabaeizadeh, Vahid Haghpanah, Abbasali Keshtkar, Shahryar Semnani, Gholamreza Roshandel, Khadijeh Adabi, Ramin Heshmat, Davood Rohani, Alireza Kia, Ehsan Hatami, Ataollah Jahangirrad, Ramin Nabizadeh, and Bagher Larijani
Journal of Gastric Cancer, 2013, Volume 13, Number 2, Page 106
M. Gulaboglu, B. Borekci, and Z. Halici
International Journal of Gynecology & Obstetrics, 2007, Volume 98, Number 2, Page 100
Shih-Wen Lin, Jin-Hu Fan, Sanford M. Dawsey, Philip R. Taylor, You-Lin Qiao, and Christian C. Abnet
International Journal of Cancer, 2011, Volume 129, Number 9, Page 2284
Chris D. Meletis and Nieske Zabriskie
Alternative and Complementary Therapies, 2007, Volume 13, Number 3, Page 132
Filip Gołkowski, Zbigniew Szybiński, Jadwiga Rachtan, Andrzej Sokołowski, Monika Buziak-Bereza, Małgorzata Trofimiuk, Alicja Hubalewska-Dydejczyk, Elwira Przybylik-Mazurek, and Bohdan Huszno
European Journal of Nutrition, 2007, Volume 46, Number 5, Page 251
Marta Rossi, Eva Negri, Roberto Foschi, Silvia Franceschi, and Carlo La Vecchia
International Journal of Cancer, 2007, Volume 120, Number 4, Page 951
Christian C. Abnet, Jin-Hu Fan, Farin Kamangar, Xiu-Di Sun, Philip R. Taylor, Jian-Song Ren, Steven D. Mark, Ping Zhao, Joseph F. Fraumeni, You-Lin Qiao, and Sanford M. Dawsey
International Journal of Cancer, 2006, Volume 119, Number 6, Page 1508

Comments (0)

Please log in or register to comment.