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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Volume 43, Issue 6


Comparison of iodine contents in gastric cancer and surrounding normal tissues

Mine Gulaboglu / Leyla Yildiz / Fehmi Celebi / Mustafa Gul / Kemal Peker
Published Online: 2005-07-05 | DOI: https://doi.org/10.1515/CCLM.2005.101


It has been suggested that iodine plays an important role in gastric cancer. Gastric cancer ranks first among the cancers in the north-eastern Anatolia region, Turkey, where iodine deficiency is common. In this study, iodine levels were determined in gastric cancer and surrounding normal tissues in 19 patients with gastric cancer. Tissue iodine levels were determined by the Foss method based on the Sandell-Kolt-hoff reaction. Tissue iodine levels were lower in gastric cancer tissue (17.8±3.4ngI/mg protein, mean±SEM) compared with surrounding normal tissue (41.7±8.0ngI/mg protein) (p<0.001). There was positive correlation between the iodine levels in gastric cancer tissue and surrounding normal tissue (r=0.845, p<0.001). There was no significant difference in iodine levels in cancer and surrounding normal tissue between male and female subjects. The iodine deficiency in our region may be one of the factors for increased gastric cancer prevalence. Our results support the hypothesis that iodine plays an important role in gastric cancer development.

Keywords: gastric cancer; iodine; tissue.


  • 1

    Biber FZ, Unak P, Yurt F. Stability of iodine content in iodized salt. In: Presentations at the Eurasia Conference on Nuclear Science and its Application, vol. 1, 2000:1073–7. Google Scholar

  • 2

    Venturi S, Donati FM, Venturi M, Venturi A, Grossi L, Guidi A. Role of iodine in evolution and carcinogenesis of thyroid, breast and stomach. Adv Clin Pathol 2000; 4: 11–7. Google Scholar

  • 3

    Venturi S, Venturi A, Cimimi D, Arduini C, Venturi M, Guidi A. A new hypothesis: iodine and gastric cancer. Eur J Cancer Prev 1993; 2: 17–23. CrossrefGoogle Scholar

  • 4

    Kupper FC, Schweigert N, Gall E, Legendre JM, Vilter H, Kloareg B. Iodine uptake in Laminariales involves extra-cellular haloperoxidase-mediated oxidation of iodide. Planta 1998; 207: 163–71. Google Scholar

  • 5

    Venturi S, Venturi M. Iodide, thyroid and stomach carcinogenesis: evolutionary story of a primitive antioxidant? Eur J Endocrinol 1999; 140: 371–2. Google Scholar

  • 6

    Elstner EF, Adamczyk R, Kromer R, Furch A. The uptake of potassium iodide and its effects as an antioxidant in isolated rabbit eyes. Ophthalmologica 1985; 191: 122–6. Google Scholar

  • 7

    Stocks P. Cancer and goitre. Biometrica 1924; 16: 364–401. CrossrefGoogle Scholar

  • 8

    Spencer JG. The influence of the thyroid gland in malignant disease. Br J Cancer 1954; 8: 393–411. CrossrefGoogle Scholar

  • 9

    Eskin BA. Iodine metabolism and breast cancer. Ann NY Acad Sci 1970; 32: 911–47. Google Scholar

  • 10

    Eskin BA. Dietary iodine and cancer risk. Lancet 1976; 8: 807–8. CrossrefGoogle Scholar

  • 11

    Venturi S, Marani L, Magni MA. Syndrome thyro-gastric. Study on the relation between elementary iodine deficiency and gastric cancer. In: Ghironzi G, Jackson CE, Schuman BM, editors. Epidemiology prevention and early detection of gastric cancer. Rome: CIC, 1987:279–81. Google Scholar

  • 12

    Scriba PC, Beckers C, Bürgi H, Escobar DR, Gembicki M, Koutras DA, et al. Goitre and iodine deficiency in Europe. Lancet 1985; 325: 1289–93. Google Scholar

  • 13

    Akarsu E. Iodine deficiency and goiter prevalence in adults living in Erzurum [in Turkish]. Thesis. Ataturk University, 2000. Google Scholar

  • 14

    WHO-UNICEF-ICCIIDD. Indicators for assessing iodine deficiency disorders and their control through salt iodination. Document WHO/NUT/1994. Google Scholar

  • 15

    Bakan E, Taysi S, Polat MF, Dalga S, Umudum Z, Bakan N, et al. Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer. Jpn J Clin Oncol 2002; 32: 162–6. CrossrefGoogle Scholar

  • 16

    Gulaboglu M. The comparison of blood, urine and gastric tissue iodine levels in patients with gastric cancer [in Turkish]. PhD Thesis. Ataturk University, 2004. Google Scholar

  • 17

    Kilbane MT, Ajjan RA, Weetman AP, Dwyer R, McDermott EW, O'Higgins NJ, et al. Tissue iodine content and serum-mediated I 125 uptake – blocking activity in breast cancer. J Clin Endocrinol Metab 2000; 85: 1245–50. Google Scholar

  • 18

    Lauber K. Iodine determination in biological material, kinetic measurement of the catalytic activity of iodide. Anal Chem 1975; 47: 769–71. CrossrefGoogle Scholar

  • 19

    Foss OP, Hankes LV, Slyke DV. A study of the alkaline ashing method for determination of protein-bound iodine in serum. Clin Chim Acta 1960; 5: 301–26. CrossrefGoogle Scholar

  • 20

    Official methods of analysis, 14th ed. Washington, DC: Association of Official Analytical Chemists, 1990. Google Scholar

  • 21

    Lampertico P. Pathology of the thyroid gland in Italy: final remarks. Pathologica 1982; 74: 400–19. Google Scholar

  • 22

    Venturi S, Gross L, Marra GA, Venturi A, Venturi M. Iodine, Helicobacter pylori, stomach cancer, evolution. European Epi-Marker 2003; 7: 1–7. Google Scholar

  • 23

    ISPEL. Mortalita per professioni in Italia negli anni 80 [in Italian]. Rome: Istituta Poligrafico dello Stato, 1995. Google Scholar

  • 24

    Hung HC, Joshipura KJ, Jiang R, Hu FB, Hunter D, Smith-Warner SA, et al. Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst 2004; 96: 1577–84. CrossrefGoogle Scholar

  • 25

    Bjelakovic G, Nikolova D, Simonetti G, Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 2004; 364: 1219–28. Google Scholar

  • 26

    Gursan N, Albayrak A, Gursan MS, Keles M. Gastric carcinomas in Erzurum region. Turk J Gastroenterol 2001; 4: 294–8. Google Scholar

  • 27

    Spitzweg C, Joba W, Eisenmenger W, Heufelder AE. Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland and gastric mucosa. J Clin Endocrinol Metab 1998; 83: 1746–51. CrossrefGoogle Scholar

  • 28

    Spitzweg C, Morris JC. The sodium iodine symporter: its pathophysiological and therapeutic implications. Clin Endocrinol 2002; 57: 559–81. CrossrefGoogle Scholar

  • 29

    Venturi S, Venturi M. Does iodine in the gastric mucosa have an ancient antioxidant role? IDD Newsl 1998; 14: 61–2. Google Scholar

  • 30

    Cocchi M, Venturi S. Iodide, antioxidant function and omega-6 and omega-3 fatty acids: a new hypothesis of a biochemical cooperation? Prog Nutr 2000; 2: 15–9. Google Scholar

  • 31

    Banerjee RK, Bose AK, Chakraborty TK, De SK, Datta AG. Peroxidase-catalysed iodotyrosine formation in dispersed cells of mouse extrathyroidal tissue. J Endocrinol 1985; 106: 159–65. CrossrefGoogle Scholar

  • 32

    Weetman AP, McGregor AM, Campbell H, Lazarus JH, Ibbertson HK, Hall R. Iodide enhances Ig-G synthesis by human peripheral blood lymphocytes in vitro. Acta Endocrinol (Copenh) 1983; 103: 210–5. Google Scholar

  • 33

    Trafford D. How to prevent and how to survive breast cancer. http://www.Trafford.com/4.dcgi/robots/01.0286.html (accessed21 February 2003). Google Scholar

  • 34

    Ingbar SH, Woeber KA. The thyroid gland. In: Williams R, editor. Textbook of endocrinology, 6th ed. New York: Wiley, 1980:118–23. Google Scholar

  • 35

    Suzuki H, Higuchi T, Sawa K, Ohtaki S, Horiuchi Y. “Endemic coast goiter” in Hokkaido, Japan. Acta Endocrinol 1965; 50: 161–70. Google Scholar

  • 36

    Ma T, Yu ZH, Lu TZ, Wang SY, Dong CF, Hu XY, et al. High-iodide endemic goitre. Chin Med J 1982; 95: 692–6. Google Scholar

About the article

Corresponding author: Mine Gulaboglu, PhD, Department of Biochemistry, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey Phone: +90-442-2360961, Fax: +90-442-2360962,

Received: 2005-01-11

Accepted: 2005-04-01

Published Online: 2005-07-05

Published in Print: 2005-06-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 43, Issue 6, Pages 581–584, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2005.101.

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