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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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1437-4331
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Volume 43, Issue 9 (Sep 2005)

Issues

Evaluation of renal function in intensive care: plasma cystatin C vs. creatinine and derived glomerular filtration rate estimates

Thierry Le Bricon
  • Laboratoire de Biochimie A, Hôpital St-Louis (AP-HP), Paris, France
/ Isabelle Leblanc
  • Service de Réanimation chirurgicale, Hôpital St-Louis (AP-HP), Paris, France
/ Mourad Benlakehal
  • Laboratoire de Biochimie A, Hôpital St-Louis (AP-HP), Paris, France
/ Cécile Gay-Bellile
  • Laboratoire de Biochimie A, Hôpital St-Louis (AP-HP), Paris, France
/ Danielle Erlich
  • Laboratoire de Biochimie B, Hôpital St-Louis (AP-HP), Paris, France
/ Said Boudaoud
  • Service de Réanimation chirurgicale, Hôpital St-Louis (AP-HP), Paris, France
Published Online: 2011-09-21 | DOI: https://doi.org/10.1515/CCLM.2005.163

Abstract

Plasma cystatin C, a new marker of glomerular filtration rate (GFR), was prospectively evaluated in surgical intensive care. Cystatin C was measured (immunonephelometry, Dade-Behring) in 10 patients selected to cover a full range of GFR (phase I) and in 28 unselected consecutive patients followed for 5days post-admission (phase II). Results were compared with 51Cr-EDTA clearance (phase I only), plasma creatinine (kinetic Jaffe, Roche), 24-h or estimated by Cockcroft and Gault (CG) creatinine clearance (CrCl), and modified diet in renal disease (MDRD)-estimated GFR. In phase I, the highest correlation with 51Cr-EDTA clearance (22–198mL/min) was noted for CG CrCl (r 2: 0.883, p<0.001). During phase II follow-up, 24-h CrCl could not be calculated in 25% of daily evaluations. Cystatin C correlated with creatinine (0.856, p<0.0001) and CG CrCl with MDRD GFR (0.926, p<0.0001) in renal failure (10–78mL/min, n=60). There was a +40% (p<0.001) median difference between cystatin C and creatinine (as a % of upper normal cut-off). Sensitivity/specificity to detect a <80mL/min CG CrCl was 88/97% for cystatin C vs. 48/100% for creatinine (laboratory cut-off). In patients with normal and stable renal function (n=14), day-to-day intra-individual variation was 7.4% for cystatin C (vs. 10.6% for creatinine). In intensive care unit surgical adult patients, CG CrCl provides an easy and cost-effective estimate of GFR. Superior to creatinine, plasma cystatin C can be measured in selected patients where CG CrCl is known to be inaccurate.

Keywords: biochemical marker; intensive care; renal failure

References

  • 1.

    Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 1992; 38: 1933–53.

  • 2.

    Gowans E, Fraser CG. Biological variation of serum and urine creatinine and creatinine clearance: ramifications for interpretation of results and patient care. Ann Clin Biochem 1988; 25: 259–63. [Crossref]

  • 3.

    Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, et al. National kidney foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 2003; 139: 137–47. [Crossref]

  • 4.

    Filler G, Bökenkamp A, Hofmann W, Le Bricon T, Martínez-Brú C, Grubb A. Cystatin C as a marker of GFR – history, indications, and future research. Clin Biochem 2005; 38: 1–8. [Crossref]

  • 5.

    Galteau MM, Guyon M, Gueguen R, Siest G. Determination of serum cystatin C: biological variation and reference values. Clin Chem Lab Med 2001; 39: 850–7. [Crossref]

  • 6.

    Knight EL, Verhave JC, Spiegelman D, Hillege HL, de Zeeuw D, Curhan GC, et al. Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney Int 2004; 65: 1416–21. [Crossref]

  • 7.

    Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 2002; 40: 221–6. [Crossref]

  • 8.

    Delanaye P, Lambermont B, Chapelle JP, Gielen J, Gerard P, Rorive G. Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units. Int Care Med 2004; 30: 980–3. [Crossref]

  • 9.

    Ahlstrom A, Tallgren M, Peltonen S, Pettila V. Evolution and predictive power of serum cystatin C in acute renal failure. Clin Nephrol 2004; 62: 344–50. [Crossref]

  • 10.

    Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31–4. [Crossref]

  • 11.

    Levey A, Greene T, Kusek J, Beck GJ, MDRD study group. A simplified equation to predict glomerular filtration rate from serum creatinine [abstract]. J Am Soc Nephrol 2000; 11: 155A.

  • 12.

    Finney H, Newman DJ, Gruber W, Merle P, Price CP. Initial evaluation of cystatin C measurement by particle-enhanced immunonephelometry on the Behring nephelometer systems (BNA, BNII). Clin Chem 1997; 43: 1016–22.

  • 13.

    Le Bricon T, Thervet E, Benlakehal M, Bousquet B, Legendre C, Erlich D. Changes in plasma cystatin C after renal transplantation and acute rejection in adults. Clin Chem 1999; 45: 2243–9.

  • 14.

    Le Bricon T, Thervet E, Froissart M, Benlakehal M, Bousquet B, Legendre C, et al. Plasma cystatin C is superior to 24-h creatinine clearance and plasma creatinine for estimation of glomerular filtration rate 3months after kidney transplantation. Clin Chem 2000; 46: 1206–7.

  • 15.

    Brochner-Mortensen J. A simple method for the determination of glomerular filtration rate. Scand J Clin Lab Invest 1972; 30: 271–4. [Crossref]

  • 16.

    Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Intern Med 1999; 130: 461–70. [Crossref]

  • 17.

    Keevil BG, Kilpatrick ES, Nichols SP, Maylor PW. Biological variation of cystatin C: implications for the assessment of glomerular filtration rate. Clin Chem 1998; 44: 1535–9.

  • 18.

    Laterza OF, Price CP, Scott MG. Cystatin C: an improved estimator of glomerular filtration rate? Clin Chem 2002; 48: 699–707.

  • 19.

    Podracka L, Feber J, Lepage N, Filler G. Intra-individual variation of cystatin C and creatinine in pediatric solid organ transplant recipients. Pediatr Transplant 2005; 9: 28–32. [Crossref]

  • 20.

    Larsson A, Malm J, Grubb A, Hansson LO. Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L. Scand J Clin Lab Invest 2004; 64: 25–30. [Crossref]

  • 21.

    Den Hollander JG, Wulkan RW, Mantel MJ, Berhout A. Is cystatin C a marker of glomerular filtration rate in thyroid dysfunction? Clin Chem 2003; 49: 1558–9. [Crossref]

  • 22.

    Cimerman N, Brguljan PM, Krasovec M, Suskovic S, Kos J. Serum cystatin C, a potent inhibitor of cysteine proteinases, is elevated in asthmatic patients. Clin Chim Acta 2000; 300: 83–95. [Crossref]

  • 23.

    Sumita S, Ujike Y, Namiki A, Watanabe H, Kawamata M, Watanabe A, et al. Suppression of the thyrotropin response to thyrotropin-releasing hormone and its association with severity of critical illness. Crit Care Med 1994; 22: 1603–9. [Crossref]

About the article

Corresponding author: T. Le Bricon, Laboratoire de Biochimie A, Hôpital St-Louis (AP-HP), 1 avenue Claude Vellefaux, 75010 Paris, France Phone: +33-1-4249-4621, Fax: +33-1-4249-9247,


Received: 2005-04-27

Accepted: 2005-07-07

Published Online: 2011-09-21

Published in Print: 2005-09-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2005.163. Export Citation

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