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Clinical Chemistry and Laboratory Medicine (CCLM)

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Volume 43, Issue 9 (Sep 2005)


Multicentre physiological reference values for some urinary component-to-creatinine (creatininium) concentration ratios

Xavier Fuentes-Arderiu
  • Laboratori Clínic, IDIBELL – Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Catalonia, Spain
/ Roser Mas-Serra
  • Roche Diagnostics, S.L., Sant Cugat del Vallès, Catalonia, Spain
/ Carmen de-Nó-Lengaran
  • Analisi Klinicoaren Zerbitzua, Galdakaoko Ospitalea, Galdakao, Basque Country, Spain
/ Francisco Espejo-López
  • Servicio de Análisis Clínicos, Hospital de Mérida, Mérida, Extremadura, Spain
/ Paula Filgueiras-Martínez
  • Servicio de Análisis Clínicos, Complexo Hospitalario Universitario Juan Canalejo, A Coruña, Galicia, Spain
/ Paula Gassiot-Cordomí
  • Laboratori Clínic, Hospital Universitari Arnau de Vilanova, Lleida, Catalonia, Spain
/ Isabel Idoate-Cervantes
  • Servicio de Análisis Clínicos, Hospital Virgen del Camino, Pamplona, Navarra, Spain
/ María Victoria Poncela-García
  • Laboratorio Análisis Clínicos, Hospital General Yagüe, Burgos, Castilla-León, Spain
/ Juan Porras-Gracia
  • Servicio de Análisis Clínicos, Hospital de la Merced, Osuna, Andalusia, Spain
/ Irene Sanz-Lobo
  • Servicio de Análisis Clínicos, Hospital General La Mancha-Centro, Alcázar de San Juan, Castilla-La Mancha, Spain
/ María del Mar Viloria-Peñas
  • Servicio de Análisis Clínicos, Hospital Universitario Virgen de Valme, Sevilla, Andalusia, Spain
/ Santiago Juvé-Cuxart
  • Roche Diagnostics, S.L., Sant Cugat del Vallès, Catalonia, Spain
Published Online: 2011-09-21 | DOI: https://doi.org/10.1515/CCLM.2005.164


Nine clinical laboratories in different regions of Spain have shared the search for reference individuals and the production of reference values for urinary component-to-creatininium concentration ratios measured in first morning urine samples using RD/Hitachi<MODULAR ANALYTICS> analysers. These urinary quantities include albumin, calcium(II), chloride, magnesium(II), phosphate, potassium ion, protein, sodium ion, urate and urea. All the logistic work was done in co-operation with the reagents' and analysers' supplier (Roche Diagnostics España, S.L., Sant Cugat del Vallès, Catalonia, Spain). From the blend of reference values obtained by each laboratory, the multicentre reference limits were estimated parametrically after mathematical transformation of original data.

Keywords: multicentre reference values; physiological reference intervals; ratio quantities; urinary components


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About the article

Corresponding author: Xavier Fuentes-Arderiu, Laboratori Clínic, IDIBELL – Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 l'Hospitalet de Llobregat, Catalonia, Spain Fax: +34-93-260-7546,

Received: 2005-05-05

Accepted: 2005-07-03

Published Online: 2011-09-21

Published in Print: 2005-09-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2005.164. Export Citation

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