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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Volume 43, Issue 9 (Sep 2005)

Issues

The Asp298 but not the C-786 genotype of the endothelial nitric oxide synthase is reduced with age in healthy Swiss men

Jörg Muntwyler
  • Cardiovascular Center Division of Cardiology, University Hospital Zurich, Zurich, Switzerland
/ Jacqueline Marti-Jaun
  • Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
/ Thomas F. Lüscher
  • Cardiovascular Center Division of Cardiology, University Hospital Zurich, Zurich, Switzerland
/ Edgar Hänseler
  • Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
/ Martin Hersberger
  • Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
Published Online: 2011-09-21 | DOI: https://doi.org/10.1515/CCLM.2005.167

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    Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H, et al. T-786→C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 1999; 99: 2864–70.

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    Wang XL, Sim AS, Wang MX, Trudinger B, Wang J. Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. FEBS Lett 2000; 471: 45–50.

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    Tesauro M, Thompson WC, Rogliani P, Qi L, Chaudhary PP, Moss J. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci USA 2000; 97: 2832–5.

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    Fairchild TA, Fulton D, Fontana JT, Gratton JP, McCabe TJ, Sessa WC. Acidic hydrolysis as a mechanism for the cleavage of the Glu(298)→Asp variant of human endothelial nitric-oxide synthase. J Biol Chem 2001; 276: 26674–9.

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    McDonald DM, Alp NJ, Channon KM. Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells. Pharmacogenetics 2004; 14: 831–9. [Crossref]

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    Casas JP, Bautista LE, Humphries SE, Hingorani AD. Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation 2004; 109: 1359–65.

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    Morris BJ, Zee RY, Schrader AP. Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals. J Clin Invest 1994; 94: 1085–9. [Crossref]

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    Hersberger M, Marti-Jaun J, Rentsch K, Hanseler E. Rapid detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 alleles by tetra-primer PCR and of the CYP2D6*5 allele by multiplex long PCR. Clin Chem 2000; 46: 1072–7.

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    Poirier O, Mao C, Mallet C, Nicaud V, Herrmann SM, Evans A, et al. Polymorphisms of the endothelial nitric oxide synthase gene – no consistent association with myocardial infarction in the ECTIM study. Eur J Clin Invest 1999; 29: 284–90.

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    Lamas S, Marsden PA, Li GK, Tempst P, Michel T. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci USA 1992; 89: 6348–52.

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    D'Agostino RB, Kannel WB, Belanger AJ, Sytkowski PA. Trends in CHD and risk factors at age 55–64 in the Framingham Study. Int J Epidemiol 1989; 18: S67–S72.

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    Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J 1986; 111: 383–90.

About the article

Corresponding author: Martin Hersberger, University Hospital Zurich, Raemistr. 100, 8091 Zurich, Switzerland Phone: +41-1-255-3473, Fax: +41-1-255-4590,


Published Online: 2011-09-21

Published in Print: 2005-09-01



Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2005.167. Export Citation

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