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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Volume 44, Issue 10 (Oct 2006)

Issues

Role of serum S100B as a predictive marker of fatal outcome following isolated severe head injury or multitrauma in males

Adriana Brondani da Rocha
  • Laboratório de Marcadores de Estresse Celular, Centro de Pesquisa em Ciências Médicas, Universidade Luterana do Brasil, Canoas, Brazil, Programa de Pós-Graduação em Diagnóstico Genético e Molecular, Universidade Luterana do Brasil, Canoas, Brazil, Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil, Canoas, Brazil and Curso de Medicina, Universidade Luterana do Brasil, Canoas, Brazil
/ Rogerio Fett Schneider
  • Programa de Pós-Graduação em Diagnóstico Genético e Molecular, Universidade Luterana do Brasil, Canoas, Brazil and Curso de Medicina, Universidade Luterana do Brasil, Canoas, Brazil
/ Gabriel R. de Freitas
  • Departamento de Neurologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
/ Charles André
  • Departamento de Neurologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
/ Ivana Grivicich
  • Laboratório de Marcadores de Estresse Celular, Centro de Pesquisa em Ciências Médicas, Universidade Luterana do Brasil, Canoas, Brazil and Programa de Pós-Graduação em Diagnóstico Genético e Molecular, Universidade Luterana do Brasil, Canoas, Brazil
/ Caroline Zanoni
  • Laboratório de Marcadores de Estresse Celular, Centro de Pesquisa em Ciências Médicas, Universidade Luterana do Brasil, Canoas, Brazil
/ Aline Fossá
  • Laboratório de Marcadores de Estresse Celular, Centro de Pesquisa em Ciências Médicas, Universidade Luterana do Brasil, Canoas, Brazil
/ Junia T. Gehrke
  • Laboratório de Marcadores de Estresse Celular, Centro de Pesquisa em Ciências Médicas, Universidade Luterana do Brasil, Canoas, Brazil
/ Geraldo Pereira Jotz
  • Curso de Medicina, Universidade Luterana do Brasil, Canoas, Brazil
/ Mauro Kaufmann
  • Unidade de Terapia Intensiva, Hospital Cristo Redentor, Porto Alegre, Brazil
/ Daniel Simon
  • Programa de Pós-Graduação em Diagnóstico Genético e Molecular, Universidade Luterana do Brasil, Canoas, Brazil and Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil, Canoas, Brazil
/ Andrea Regner
  • Laboratório de Marcadores de Estresse Celular, Centro de Pesquisa em Ciências Médicas, Universidade Luterana do Brasil, Canoas, Brazil, Programa de Pós-Graduação em Diagnóstico Genético e Molecular, Universidade Luterana do Brasil, Canoas, Brazil, Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil, Canoas, Brazil, Curso de Medicina, Universidade Luterana do Brasil, Canoas, Brazil and SAMU, Hospital Municipal de Pronto Socorro de Porto Alegre, Porto Alegre, Brazil
Published Online: 2006-10-10 | DOI: https://doi.org/10.1515/CCLM.2006.218

Abstract

Background: Severe traumatic brain injury (TBI) is associated with a 30%–70% mortality rate. S100B has been proposed as a biomarker for indicating outcome after TBI. Nevertheless, controversy has arisen concerning the predictive value of S100B for severe TBI in the context of multitrauma. Therefore, our aim was to determine whether S100B serum levels correlate with primary outcome following isolated severe TBI or multitrauma in males.

Methods: Twenty-three consecutive male patients (age 18–65 years), victims of severe TBI [Glasgow Coma Scale (GCS) 3–8] (10 isolated TBI and 13 multitrauma with TBI) and a control group consisting of eight healthy volunteers were enrolled in this prospective study. Clinical outcome variables of severe TBI comprised: survival, time to intensive care unit (ICU) discharge, and neurological assessment [Glasgow Outcome Scale (GOS) at ICU discharge]. Venous blood samples were taken at admission in the ICU (study entry), 24 h later, and 7 days later. Serum S100B concentration was measured by an immunoluminometric assay.

Results: At study entry (mean time 10.9 h after injury), mean S100B concentrations were significantly increased in the patient with TBI (1.448 μg/L) compared with the control group (0.037 μg/L) and patients with fatal outcome had higher mean S100B (2.10μg/L) concentrations when compared with survivors (0.85 μg/L). In fact, there was a significant correlation between higher initial S100B concentrations and fatal outcome (Spearman's =0.485, p=0.019). However, there was no correlation between higher S100B concentrations and the presence of multitrauma. The specificity of S100B in predicting mortality according to the cut-off of 0.79 μg/L was 73% at study entry.

Conclusions: Increased serum S100B levels constitute a valid predictor of unfavourable outcome in severe TBI, regardless of the presence of associated multitrauma.

Clin Chem Lab Med 2006;44:1234–42.

Keywords: biomarkers; humans; multitrauma; outcome; S100B protein; traumatic brain injury

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About the article

Corresponding author: Andrea Regner, Laboratório de Marcadores de Estresse Celular, Centro de Pesquisa em Ciências Médicas, ULBRA, Avenida Farroupilha, 8001, Prédio 22, 5 andar, CEP 92425-900, Bairro São José, Canoas, RS, Brazil Phone: +55-51-477-9219,


Received: April 27, 2006

Accepted: July 4, 2006

Published Online: 2006-10-10

Published in Print: 2006-10-01


Citation Information: Clinical Chemical Laboratory Medicine, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.218. Export Citation

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