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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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The importance of metrological traceability on the validity of creatinine measurement as an index of renal function: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)

Mauro Panteghini1 / Gary L. Myers2 / W. Greg Miller3 / Neil Greenberg4 /





Corresponding author: Prof. Mauro Panteghini, Laboratorio Analisi Chimico-Cliniche, Ospedale Luigi Sacco, Via GB Grassi, 20157 Milano, Italy Phone: +39-02-39042806, Fax: +39-02-50319835,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 10, Pages 1287–1292, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.234, October 2006


The glomerular filtration rate (GFR) is currently considered the best overall index of kidney function. The possibility that laboratories might routinely report an estimated GFR has become practically feasible with the development of a formula, the “four-variable” Modification of Diet in Renal Disease study (MDRD) equation that uses age, sex, race, and serum creatinine parameters. However, a limitation of this equation for general implementation in healthcare is related to the use of differently calibrated creatinine measurement procedures among laboratories. The only way to achieve universal implementation of the GFR prediction equation, with the associated clinical benefits for patients, is, therefore, to promote worldwide standardization of methods to determine creatinine, together with the introduction of a revised GFR-estimating equation appropriate for use with standardized creatinine methods.

Clin Chem Lab Med 2006;44:1287–92.

Keywords: calibration; creatinine; glomerular filtration rate; kidney function tests; reference standards; traceability

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