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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

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Volume 44, Issue 12


Analytical performance and clinical utility of the INNOTEST® PHOSPHO-TAU(181P) assay for discrimination between Alzheimer's disease and dementia with Lewy bodies

Hugo Vanderstichele / Karen De Vreese / Kaj Blennow / Niels Andreasen
  • Neurotec, Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Christian Sindic / Adrian Ivanoiu / Harald Hampel / Katharina Bürger / Lucilla Parnetti / Alessia Lanari / Allesandro Padovani / Monica DiLuca / Miriam Bläser / Annika Ohrfelt Olsson / Hans Pottel / Frank Hulstaert / Eugeen Vanmechelen
Published Online: 2006-12-13 | DOI: https://doi.org/10.1515/CCLM.2006.258


Background: Total tau (T-tau) and β-amyloid(1-42) (Aβ1-42) levels in cerebrospinal fluid (CSF) can differentiate Alzheimer's disease (AD) from normal aging or depressive pseudo-dementia. Differential diagnosis from dementia with Lewy bodies (DLB) in clinical settings is difficult.

Methods: The analytical performance of the INNOTEST® PHOSPHO-TAU(181P) assay was validated in terms of selectivity, sensitivity, specificity, precision, robustness, and stability. Clinical utility of the assay alone, or combined with T-tau and Aβ1-42, for discrimination of AD (n=94) from patients suffering from DLB (n=60) or from age-matched control subjects (CS) (n=60) was assessed in a multicenter study.

Results: CSF concentrations of tau phosphorylated at threonine 181 (P-tau181P) in AD was significantly higher than in DLB and CS. Discriminant analysis, a classification tree, and logistic regression showed that P-tau181P was the most statistically significant single variable of the three biomarkers for discrimination between AD and DLB.

Conclusions: P-tau181P quantification is a robust and reliable assay that may be useful in discriminating AD from DLB.

Clin Chem Lab Med 2006;44:1472–80.

Keywords: Alzheimer's disease; cerebrospinal fluid; dementia; diagnosis; performance; P-tau181P


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About the article

Corresponding author: Hugo Vanderstichele, PhD, Innogenetics, Industriepark Zwijnaarde 7, P.O. Box 4, 9052 Gent, Belgium Phone: +32-9-2410711, Fax: +32-9-2410907

Received: 2006-05-13

Accepted: 2006-09-14

Published Online: 2006-12-13

Published in Print: 2006-12-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 44, Issue 12, Pages 1472–1480, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.258.

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Movement Disorders, 2009, Volume 24, Number 15, Page 2203
Brit Mollenhauer and Claudia Trenkwalder
Movement Disorders, 2009, Volume 24, Number 10, Page 1411
F. Deisenhammer, R. Egg, G. Giovannoni, B. Hemmer, A. Petzold, F. Sellebjerg, C. Teunissen, and H. Tumani
European Journal of Neurology, 2009, Volume 16, Number 6, Page 760
Klaus Tatsch
European Journal of Nuclear Medicine and Molecular Imaging, 2008, Volume 35, Number S1, Page 51
Dag Aarsland, Martin Kurz, Mona Beyer, Kolbjørn Bronnick, Sabine Piepenstock Nore, and Clive Ballard
Dementia and Geriatric Cognitive Disorders, 2008, Volume 25, Number 3, Page 195
International Journal of Geriatric Psychiatry, 2007, Volume 22, Number 9, Page 937
O. Sobek, P. Adam, and J. Svatonova
European Journal of Neurology, 2007, Volume 14, Number 6, Page e14

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