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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1437-4331
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Volume 44, Issue 12

Issues

Insulin resistance and enhanced protein glycation in men with prehypertension

Viswanathan Sathiyapriya
  • Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Hanumanthappa Nandeesha
  • Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zachariah Bobby
  • Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Purushothaman Pavithran
  • Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nambiar Selvaraj
  • Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nadaradjan Rattina Dasse
  • Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2006-12-13 | DOI: https://doi.org/10.1515/CCLM.2006.264

Abstract

Background: Insulin resistance and hyperinsulinemia have been reported among patients with hypertension. However, little is known about insulin sensitivity in subjects with prehypertension. The aim of this study was to assess whether the metabolic characteristics of insulin resistance syndrome are present in prehypertensive subjects.

Methods: Plasma fasting glucose, lipid profile, glycated hemoglobin, fructosamine and insulin concentrations were evaluated in 35 prehypertensive subjects and in 30 healthy controls.

Results: Prehypertensive subjects had significantly higher levels of plasma insulin and triglycerides compared with normotensive subjects. The level of high-density lipoprotein cholesterol was significantly lower in prehypertensive subjects compared with controls. There was no significant difference in total cholesterol and low-density lipoprotein cholesterol levels. The levels of glycated hemoglobin and fructosamine were also significantly higher in prehypertensive subjects compared with controls. Plasma insulin levels were positively correlated with systolic and diastolic blood pressure in prehypertensive subjects. Similarly, plasma insulin was significantly positively correlated with triglyceride and negatively correlated with high-density lipoprotein cholesterol.

Conclusions: The present study indicates that prehypertensive non-diabetic subjects have higher insulin resistance and protein glycation compared to normotensive subjects, which may contribute to the pathogenesis of prehypertension.

Clin Chem Lab Med 2006;44:1457–61.

Keywords: hyperinsulinemia; hypertension; insulin resistance; prehypertension; protein glycation

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About the article

Corresponding author: Dr. Zachariah Bobby, Assistant Professor, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry-605 006, India Phone: +91-413-2273078, Fax: +91-413-2372067,


Received: 2006-07-14

Accepted: 2006-08-31

Published Online: 2006-12-13

Published in Print: 2006-12-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 44, Issue 12, Pages 1457–1461, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.264.

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