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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2017: 3.556

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 44, Issue 12


Point-of-care C-reactive protein testing in febrile children in general practice

Miriam Monteny / Marjolein H. ten Brinke / Jocelyn van Brakel / Yolanda B. de Rijke
  • Department of Clinical Chemistry, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marjolein Y. Berger
Published Online: 2011-09-21 | DOI: https://doi.org/10.1515/CCLM.2006.270


Background: Point-of-care testing for C-reactive protein (CRP) may be helpful in differentiating viral from bacterial infection. Such a device should give results comparable to laboratory testing. The aim was to evaluate two point-of-care CRP tests (Nycocard and QuikRead) in febrile children in general practice, compared to a reference immunoturbidimetric assay.

Methods: A cross-sectional study was carried out of febrile children aged 3months to 6years presented to a general practice out-of-hours service. Children were visited at home where blood was taken for tests, within 24h after presentation. The Nycocard test was performed at home, whereas the QuikRead and reference test were performed in the laboratory.

Results: A total of 76 children were enrolled. All three CRP tests were performed in 59 children. The mean difference between the reference test and Nycocard and QuikRead was 0.6 and −6.1mg/L, respectively. The slope of the Passing-Bablok regression was 0.95 (95% CI 0.9–1.0) and 0.83 (95% CI 0.81–0.85) for the Nycocard and QuikRead tests, respectively.

Conclusions: Up to a concentration of 160mg/L, the Nycocard test correlated well with the reference test, while the QuikRead test underestimated concentrations above 60mg/L. The Nycocard test seems a good candidate for CRP point-of-care testing in general practice.

Clin Chem Lab Med 2006;44:1428–32.

Keywords: child; C-reactive protein; family practice; fever; point-of-care systems


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About the article

Corresponding author: Marjolein Y. Berger, MD, PhD, Erasmus MC, Department of General Practice, Room Ff 322, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands Phone: +31-10-4087631, Fax: +31-10-4089491,

Received: 2006-08-14

Accepted: 2006-09-19

Published Online: 2011-09-21

Published in Print: 2006-12-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 44, Issue 12, Pages 1428–1432, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.270.

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