Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

See all formats and pricing


Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

Lipoprotein lipase gene polymorphism at the PvuII locus and serum lipid levels in Guangxi Hei Yi Zhuang and Han populations

Ruixing Yin1 / Yong Wang2 / Guangqin Chen3 / Weixiong Lin4 / Dezhai Yang5 / Shangling Pan6







Corresponding author: Dr. Yin Ruixing, Department of Cardiology, Institute of Cardiovascular Diseases, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China Phone: +86-771-5358269, Fax: +86-771-5353342

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 12, Pages 1416–1421, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.273, December 2006

Publication History

July 28, 2006
September 24, 2006


Background: Hei Yi (which means black worship and black dressing) Zhuang is a specific subgroup of the Zhuang nationality in China. Little is known about the relationship between genetic factors and lipid profiles in this population. Therefore, the present study was undertaken to compare the effects of lipoprotein lipase gene polymorphism at the PvuII locus on lipid levels in the Guangxi Hei Yi Zhuang and Han populations.

Methods: A total of 325 Hei Yi Zhuang subjects aged from 20 to 80 years were surveyed using stratified randomized cluster sampling. Serum levels of lipids and apolipoproteins were measured. Gene polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism. The results were compared with those for 331 matched Han subjects living in the same district.

Results: Serum levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol and apolipoprotein B were significantly lower in Hei Yi Zhuang than in Han subjects (p<0.05–0.01), whereas the levels of high-density lipoprotein cholesterol and the ratio of apolipoprotein A1 to apolipoprotein B were significantly higher in Hei Yi Zhuang than in Han subjects (both p<0.01). The allelic frequencies for P+ and P– were 52.92% and 47.08% in Hei Yi Zhuang, and 58.46% and 41.54% in Han subjects (p<0.05), respectively. The frequencies of P+P+, P+P– and P–P– genotypes were 23.08%, 59.69% and 17.23% in Hei Yi Zhuang, and 29.31%, 58.31% and 12.38% in Han subjects (p>0.05), respectively. There were no significant differences or no significant correlation between serum lipid parameters and genotypes in Hei Yi Zhuang or Han subjects, or for the combined population of Hei Yi Zhuang and Han (all p>0.05).

Conclusions: The allelic frequencies of the lipoprotein lipase gene at the PvuII locus in Hei Yi Zhuang were different from those in Han subjects, but the genotypic frequencies in Hei Yi Zhuang subjects were not different from those in Han subjects. There was no significant correlation between polymorphism of the lipoprotein lipase gene at the PvuII site and serum lipid levels in the two ethnic groups.

Clin Chem Lab Med 2006;44:1416–21.

Keywords: apolipoproteins; gene; Hei Yi Zhuang nationality; lipids; lipoprotein lipase; polymorphism

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Peng Hu, Yuan Han Qin, Feng Ying Lei, Juan Pei, Bo Hu, and Ling Lu
International Journal of Molecular Sciences, 2011, Volume 12, Number 12, Page 5604
Yin Ruixing, Yang Dezhai, Li Shuquan, Chen Yuming, Yang Hanjun, Feng Qiming, Pan Shangling, Lin Weixiong, Tan Jing, and Li Yiyang
Public Health Nutrition, 2009, Volume 12, Number 06, Page 816
Yin Ruixing, Wu Jinzhen, Lin Weixiong, Chen Yuming, Yang Dezhai, and Pan Shangling
Journal of Hypertension, 2009, Volume 27, Number 2, Page 251
G. S. Sagoo, I. Tatt, G. Salanti, A. S. Butterworth, N. Sarwar, M. van Maarle, J. W. Jukema, B. Wiman, J. J. P. Kastelein, A. M. Bennet, U. de Faire, J. Danesh, and J. P. T. Higgins
American Journal of Epidemiology, 2008, Volume 168, Number 11, Page 1233

Comments (0)

Please log in or register to comment.