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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
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Volume 44, Issue 2 (Feb 2006)

Issues

Establishment of an indocyanine green test using an automatic chemistry analyzer

Moon-Woo Seong / Sang-Hoon Song / Joo-Young Oh / Joong-Won Park / Do-Hoon Lee
Published Online: 2011-09-21 | DOI: https://doi.org/10.1515/CCLM.2006.036

Abstract

The indocyanine green (ICG) clearance test has been used to assess the reserve of hepatic function. This method is based on the spectrometric measurement of its plasma concentration at maximum wavelength of 805nm, which requires a spectrophotometer and associated maintenance. We established an ICG clearance test using a Toshiba 200FR automatic chemistry analyzer that can be tuned to a wavelength of approximately 805nm. Five pooled sera spiked from 0 to 4.0mg/dL were analyzed for linearity test and precision was determined at five levels in the range 0.1–2.0mg/dL. The ICG retention rate at 15min (R15) was determined for 38 patients using a conventional method and our method. The ICG clearance test using the automatic chemistry analyzer showed good linearity, and precision ranged from 0.3% to 1.0% for within-run CVs and from 0.6% to 4.7% for total CVs. The degree of agreement between the two methods was also acceptable (mean difference of 1.5%). It is expected that the ICG test using the automatic chemistry analyzer can replace the conventional ICG clearance test, considering the excellent agreement, good precision and linearity over a clinically relevant range.

Keywords: comparison; hepatic function; indocyanine green (ICG); TBA 200FR spectrophotometer

References

  • 1.

    Imamura H, Sano K, Sugawara Y, Kokudo N, Makuuchi M. Assessment of hepatic reserve for indication of hepatic resection: decision tree incorporating indocyanine green test. J Hepatobiliary Pancreat Surg 2005; 12:16–22.Google Scholar

  • 2.

    Kim S, Park R, Lee KR, Kim JH, Kwon OH. Comparison of the indocyanine green clearance test using conventional blood sampling and finger monitoring methods. Korean J Lab Med 2003; 23:88–91.Google Scholar

  • 3.

    Maarek JM, Holschneider DP, Harimoto J, Yang J, Scremin OU, Rubinstein EH. Measurement of cardiac output with indocyanine green transcutaneous fluorescence dilution technique. Anesthesiology 2004; 100:1476–83.CrossrefGoogle Scholar

  • 4.

    Mitra S, Chamney P, Greenwood R, Farrington K. Serial determinations of absolute plasma volume with indocyanine green during hemodialysis. J Am Soc Nephrol 2003; 14:2345–51.CrossrefGoogle Scholar

  • 5.

    Miyagawa S, Makuuchi M, Kawasaki S, Kakazu T. Criteria for safe hepatic resection. Am J Surg 1995; 169:589–94.CrossrefGoogle Scholar

  • 6.

    Poon RT, Fan ST. Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome. Liver Transpl 2004; 10:S39–45.CrossrefGoogle Scholar

  • 7.

    Stanga PE, Lim JI, Hamilton P. Indocyanine green angiography in chorioretinal diseases: indications and interpretation: an evidence-based update. Ophthalmology 2003; 110:15–21.CrossrefGoogle Scholar

  • 8.

    Tsubono T, Todo S, Jabbour N, Mizoe A, Warty V, Demetris AJ, et al. Indocyanine green elimination test in orthotopic liver recipients. Hepatology 1996; 24:1165–71.CrossrefGoogle Scholar

  • 9.

    Wakabayashi H, Ishimura K, Izuishi K, Karasawa Y, Maeta H. Evaluation of liver function for hepatic resection for hepatocellular carcinoma in the liver with damaged parenchyma. J Surg Res 2004; 116:248–52.CrossrefGoogle Scholar

  • 10.

    Cherrick GR, Stein SW, Leevy CM, Davidson CS. Indocyanine green: observations on its physical properties, plasma decay, and hepatic extraction. J Clin Invest 1960; 39:592–600.CrossrefGoogle Scholar

  • 11.

    Owen VM. Estimation of indocyanine green concentrations. Clin Biochem 1973; 6:132–5.CrossrefGoogle Scholar

  • 12.

    Landsman ML, Kwant G, Mook GA, Zijlstra WG. Light-absorbing properties, stability, and spectral stabilization of indocyanine green. J Appl Physiol 1976; 40:575–83.Google Scholar

  • 13.

    Lau H, Man K, Fan ST, Yu WC, Lo CM, Wong J. Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy. Br J Surg 1997; 84:1255–9.Google Scholar

About the article

Corresponding author: Dr. Do-Hoon Lee, Center for Clinical Services, National Cancer Center, 809 Madu-1-dong, Ilsandong-gu, Goyang 410-769, Korea Phone: +82-31-920-1734, Fax: +82-31-920-1738,


Received: 2005-09-12

Accepted: 2005-11-15

Published Online: 2011-09-21

Published in Print: 2006-02-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.036.

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©2006 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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