Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

See all formats and pricing


Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

A longitudinal evaluation of urinary glycosaminoglycan excretion in normoalbuminuric type 1 diabetic patients

Pierina De Muro1 / Pietro Fresu2 / Giancarlo Tonolo3 / Mario Maioli4 / Giovanni Battista Cherchi5 / Antonio Murgia6 / Cristina Ibba7 / Giovanni Maria Sanna8 / Gian Mario Cherchi9










Corresponding author: Dr. Pierina De Muro, Department of Physiological, Biochemical and Cellular Science, University of Sassari, via Muroni 25, 07100 Sassari, Italy Phone: +39-079-228606, Fax: +39-079-228615,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 5, Pages 561–567, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.097, May 2006

Publication History

November 10, 2005
February 6, 2006
Published Online:


Background: Previously, we found high urinary glycosaminoglycan (GAG) concentration, together with an altered electrophoretic pattern, in normoalbuminuric type 1 diabetic subjects with hemoglobin A1c (HbA1c) ≥8.0%. The purpose of this study was long-term evaluation of GAG excretion variations in these patients compared to those with HbA1c <8.0% at baseline who maintained better metabolic control over time.

Methods: We enrolled 26 normotensive, normoalbuminuric type 1 diabetic patients and divided them into two groups according to mean HbA1c levels during the follow-up period. GAGs were isolated from 24-h urine samples on two separate occasions, at baseline and after a mean (±SD) follow-up of 6.8±1.1 years.

Results: All patients remained normoalbuminuric at follow-up, and had normal urinary α1-microglobulin levels. In patients with HbA1c <8.0%, total GAG levels and low sulfated chondroitin sulfate-proteoglycan/chondroitin sulfate ratio were almost unchanged during the follow-up period. In contrast, these increased in patients with HbA1c≥8.0% and were significantly related to both HbA1c levels and the duration of poor glycemic control.

Conclusions: Our results show a strong influence of hyperglycemic environment on GAG metabolism in diabetes and indicate that the distribution pattern of urinary GAGs, besides their total concentration, may be predictive of altered GAG metabolism in type 1 diabetes.

Keywords: glyco-metabolic control; low sulfated chondroitin sulfate-proteoglycan; normoalbuminuria; type 1 diabetes mellitus; urinary glycosaminoglicans

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Antonio Junior Lepedda, Laura Fancellu, Elisabetta Zinellu, Pierina De Muro, Gabriele Nieddu, Giovanni Andrea Deiana, Piera Canu, Daniela Concolino, Simona Sestito, Marilena Formato, and Gianpietro Sechi
BioMed Research International, 2013, Volume 2013, Page 1
D. P. K. Ng, A. Salim, Y. Liu, L. Zou, F. G. Xu, S. Huang, H. Leong, and C. N. Ong
Diabetologia, 2012, Volume 55, Number 2, Page 499
Ferruccio Ceriotti, Piero Cappelletti, Marco Caputo, Francesca Di Serio, Gianni Messeri, Cosimo Ottomano, Mario Plebani, and Giuliano Soffiati
Clinical Chemistry and Laboratory Medicine, 2012, Volume 50, Number 1
Agnès Matheson, Mark D. P. Willcox, Judith Flanagan, and Bradley J. Walsh
Diabetes/Metabolism Research and Reviews, 2010, Volume 26, Number 3, Page 150

Comments (0)

Please log in or register to comment.