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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
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Factor V Leiden, prothrombin G20210A substitution and hormone therapy: indications for molecular screening

Maria Grazia Andreassi1 / Nicoletta Botto2 / Silvia Maffei3

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Corresponding author: Maria Grazia Andreassi, CNR-Institute of Clinical Physiology, G. Pasquinucci Hospital, Via Aurelia Sud-Montepepe, 54100 Massa, Italy Phone: +39-0585-493646, Fax: +39-0585-493601,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 5, Pages 514–521, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.103, May 2006

Publication History

Received:
January 10, 2006
Accepted:
February 6, 2006

Abstract

Venous thromboembolism is a well-known complication of oral contraception and hormonal replacement therapy. Inherited thrombophilia is viewed as an important determinant in modulating the effects of estrogens on thrombotic risk. An increasing number of kits for thrombophilic mutations [factor V Leiden, G20210A prothrombin and methylenetetrahydrofolate reductase (MTHFR) C677T genes] are becoming commercially available, and screening for inherited thrombotic risk is among the most requested genetic tests in molecular diagnostic laboratories. However, the question of routine genetic screening for thrombophilia before prescribing hormones is still a matter of debate. The purpose of this article is to discuss the usefulness and practical applications of thrombotic genetic testing to identify which women should be tested to improve both the safety and efficacy of individualized estrogen therapy.

Keywords: genetic testing; hormonal replacement therapy; inherited thrombophilia; oral contraception, thrombotic risk

Citing Articles

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[2]
Verena Gartner, Michael Weber, and Sabine Eichinger
Contraception, 2008, Volume 78, Number 5, Page 392
[3]
N. Botto, S. Maffei, S. Manfredi, M. G. Colombo, A. M. Mazzone, and M G. Andreassi
Climacteric, 2011, Volume 14, Number 1, Page 25

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