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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Volume 44, Issue 7 (Jul 2006)

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Cardiac troponin T and amino-terminal pro-natriuretic peptide concentrations in fetuses in the second trimester and in healthy neonates

Giuliana Fortunato
  • Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy and CEINGE Biotecnologie Avanzate S.C.a.r.l., Naples, Italy
/ Patrizia Carandente Giarrusso
  • Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy
/ Pasquale Martinelli
  • Unità di Cardiologia Fetale, Dipartimento di Ginecologia ed Ostetricia, Università di Napoli Federico II, Naples, Italy
/ Gabriella Sglavo
  • Unità di Cardiologia Fetale, Dipartimento di Ginecologia ed Ostetricia, Università di Napoli Federico II, Naples, Italy
/ Michele Vassallo
  • Unità di Cardiologia Fetale, Dipartimento di Ginecologia ed Ostetricia, Università di Napoli Federico II, Naples, Italy
/ Luigi Tomeo
  • Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy
/ Michelangelo Rea
  • Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy
/ Dario Paladini
  • Unità di Cardiologia Fetale, Dipartimento di Ginecologia ed Ostetricia, Università di Napoli Federico II, Naples, Italy
Published Online: 2006-06-16 | DOI: https://doi.org/10.1515/CCLM.2006.144

Abstract

We measured the concentrations of cardiac troponin T (cTnT) and amino-terminal pro-natriuretic peptide (NT-proBNP) in umbilical cord blood during the second trimester (20–25weeks of gestation) and at delivery in 109 uncomplicated pregnancies to define reference values. Using the 97.5th percentile, the upper reference limits for cTnT and NT-proBNP were 0.308ng/mL and 5402pg/mL in fetuses in the second trimester, and 0.038ng/mL and 1690pg/mL in healthy neonates, respectively. We also evaluated whether labor and delivery mode affected the concentrations of the two analytes. We found significantly higher (p<0.001) umbilical blood NT-proBNP and cTnT levels at 20–25weeks of gestation than at term. In addition, within the term group, NT-proBNP concentrations were significantly higher in women delivering by elective cesarean section than in women delivering spontaneously (p<0.001), and higher than in women delivering by cesarean section during active labor. This indicates that the decrease in NT-proBNP levels is probably due to labor rather than delivery mode. Finally, we confirmed the at-birth reference values previously established for cTnT and NT-proBNP.

Clin Chem Lab Med 2006;44:834–6.

Keywords: amino-terminal pro-natriuretic peptide (NT-proBNP); cardiac troponin T (cTnT); reference value; 2nd and 3rd trimesters of gestation

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About the article

Corresponding author: Giuliana Fortunato, Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, via S. Pansini 5, 80131 Napoli, Italy Fax: +39-081-7462404,


Received: 2006-01-26

Accepted: 2006-03-13

Published Online: 2006-06-16

Published in Print: 2006-07-01



Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.144. Export Citation

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