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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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1437-4331
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Volume 44, Issue 7 (Jul 2006)

Issues

Evaluation of clinical markers of atherosclerosis in young and elderly Japanese adults

Takanobu Hara
  • Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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/ Noboru Takamura
  • Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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/ Saori Akashi
  • Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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/ Mio Nakazato
  • Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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/ Takahiro Maeda
  • Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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/ Mitsuhiro Wada
  • Department of Clinical Pharmacy, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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/ Kenichiro Nakashima
  • Department of Clinical Pharmacy, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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/ Yasuyo Abe
  • Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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/ Yosuke Kusano / Kiyoshi Aoyagi
  • Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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Published Online: 2011-09-21 | DOI: https://doi.org/10.1515/CCLM.2006.149

Abstract

Background: In order to be able to take preventative measures early in life against the development of atherosclerosis, it is important to evaluate profiles of subclinical atherosclerosis, especially among young adults.

Methods: We screened plasma homocysteine levels, highly sensitive C-reactive protein levels and carotid intima-media thickness in young and elderly adults.

Results: Among both young and elderly adults, plasma homocysteine and highly sensitive C-reactive protein were significantly lower in females than in males. Highly sensitive C-reactive protein was significantly lower in young adults than in elderly adults, and homocysteine was lower (but not significantly) in young adults than in elderly adults. Among young adults, mean carotid intima-media thickness was lower (but not significantly) in females than in males. Among elderly adults, mean carotid intima-media thickness was significantly lower in females than in males. Among both males and females, mean carotid intima-media thickness was significantly higher in elderly adults than in young adults.

Conclusions: These results demonstrate basic profiles of atherosclerosis markers in young and elderly Japanese adults. Further study is needed to evaluate measures developed for application in early adulthood to prevent atherosclerosis.

Clin Chem Lab Med 2006;44:824–9.

Keywords: carotid intima-medica thickness; elderly adults; highly sensitive C-reactive protein; homocysteine; young adults

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About the article

Corresponding author: Noboru Takamura, MD, PhD, Associate Professor, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan Phone: +81-95-849-7066, Fax: +81-95-849-7069,


Received: 2006-01-05

Accepted: 2006-03-30

Published Online: 2011-09-21

Published in Print: 2006-07-01


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.149.

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©2006 by Walter de Gruyter Berlin New York. Copyright Clearance Center

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