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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 44, Issue 7


Establishment of detailed reference values for luteinizing hormone, follicle stimulating hormone, estradiol, and progesterone during different phases of the menstrual cycle on the Abbott ARCHITECT® analyzer

Reto Stricker / Raphael Eberhart / Marie-Christine Chevailler / Frank A. Quinn / Paul Bischof
  • Laboratoire d'Hormonologie Maternité, Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ René Stricker
Published Online: 2011-09-21 | DOI: https://doi.org/10.1515/CCLM.2006.160


During a normal menstrual cycle, serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and progesterone can vary widely between cycles for the same woman, as well as between different woman. Reliable reference values based on the local population are important for correct interpretation of laboratory results. The purpose of our study was to determine detailed reference values for these hormones throughout the menstrual cycle using the Abbott ARCHITECT system. From 20 volunteers (age 20–36years) with normal cycles and no use of oral contraceptives, samples were taken every day during their cycle. Volunteers received three vaginal ultrasound examinations (days 10 and 13, and 1 or 2days after ovulation) to measure follicular and corpus luteum development. Hormone levels were measured using the corresponding ARCHITECT assay and were synchronized to the LH peak. Median, and 5th and 95th percentile values were determined for each day of the cycle, as well as for early follicular (days −15 to −6), late follicular (days −5 to −1), LH peak (day 0), early luteal (+1 to +4), mid-luteal (days +5 to +9), and late luteal (days +10 to +14) phases of the cycle. Based on our data, we were able to establish detailed reference values for LH, FSH, estradiol, and progesterone, which should aid in the interpretation of results for these reproductive hormones in a variety of circumstances.

Clin Chem Lab Med 2006;44:883–7.

Keywords: ARCHITECT analyzer; estradiol; follicle-stimulating hormone; luteinizing hormone; progesterone; reference values


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About the article

Corresponding author: Reto Stricker, DIANALAB SA, 6 rue de la Colline, Geneva, Switzerland

Received: 2006-02-01

Accepted: 2006-04-18

Published Online: 2011-09-21

Published in Print: 2006-07-01

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 44, Issue 7, Pages 883–887, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2006.160.

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