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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 45, Issue 1


Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area

Chaur-Jong Hu / Chun-Hsiung Wang
  • Department of Cardiology, Taipei City Hospital, Renai branch, Taipei, Taiwan and Department of Safety, Health & Environmental Engineering, National United University, Miao-Li, Taiwan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jui-Heng Lee / Chih-Min Hsieh / Chia Chi Cheng / Shu-Chen Chang / Chee Jen Chang


Background: Cardiovascular diseases (CVDs) are the leading cause of death in most countries of the world. In this study, associations between CVDs and polymorphisms of angiotensin-converting enzyme (ACE), atrial natriuretic peptide (ANP), β2-adrenal receptor (B2AR) and endothelial nitric oxide synthase (ENOS) genes were explored in a community-based setting.

Methods: Between March and May 2001, 1740 subjects ≥35 years from the Matsu area in Taiwan were recruited to this study, representing 71.6% of the target population in Matsu. After informed consent was obtained during an interview, physical examination, resting ECG, serum biochemical profile and a questionnaire survey were used to obtain information. Genomic DNA was also collected and analyzed. Owing to technical limitations, 1186 samples were analyzed. Genetic polymorphisms of the genes in question were investigated using PCR and restriction fragment length polymorphism (RFLP). The distribution of allele frequencies for these genes was derived for stroke, coronary artery disease, hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia and overweight subgroups.

Results: The ENOS Glu298Asp polymorphism was associated with hypercholesterolemia (odds ratio 0.658, 95%CI 0.460–0.940; p=0.025) and the ACE D/I variant was associated with hypertriglyceridemia (odds ratio 0.722, 95%CI 0.536–0.973; p=0.033). Polymorphisms of the other genes were not associated with any of the disease groups.

Conclusions: This community-based study reveals that genetic factors might play a role in the metabolism of lipids. The genetic risk for CVDs needs further investigation.

Clin Chem Lab Med 2007;45:20–5.

Keywords: angiotensin-converting enzyme (ACE); atrial natriuretic peptide (ANP); β2-adrenal receptor (B2AR); cardiovascular diseases; community-based; endothelial nitric oxide synthase (ENOS); polymorphisms

About the article

Corresponding author: Chee Jen Chang, Graduate Institute of Basic Medical Science, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan Phone:+886-3-328-1200 ext. 8878, Fax: +886-3-328-0170,

Received: September 28, 2006

Accepted: October 8, 2006

Published in Print: 2007-01-01

Citation Information: Clinical Chemical Laboratory Medicine, Volume 45, Issue 1, Pages 20–25, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2007.014.

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