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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


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CD36 polymorphism and its relationship with body mass index and coronary artery disease in a Korean population

Yeo Min Yun1 / Eun Young Song2 / Sang Hoon Song3 / Junghan Song4 / Jin Q. Kim5

1Department of Laboratory Medicine, Konkuk University College of Medicine, Seoul, Korea

2Department of Laboratory Medicine, Konkuk University College of Medicine, Seoul, Korea

3Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea

4Department of Laboratory Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Korea and Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea

5Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea

Corresponding author: Jin Q. Kim, Department of Laboratory Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea Fax: +82-2-745-6653,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 10, Pages 1277–1282, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: https://doi.org/10.1515/CCLM.2007.270, October 2007

Publication History

Received:
2007-02-09
Accepted:
2007-05-21
Published Online:
2007-10-10

Abstract

Background: CD36 is a multifunctional membrane receptor and a cell-adhesion molecule that is expressed in platelets, monocytes/macrophages, microvascular endothelial cells, cardiac monocytes and adipocytes. In this study, we investigated whether genetic polymorphisms of the CD36 gene are associated with risk of coronary artery disease (CAD) in a Korean population.

Methods: PCR and polyacrylamide gel electrophoresis or PCR-restriction fragment length polymorphism assays were performed to analyze the following CD36 gene polymorphisms: a (TG) repeat in intron 3 and the base substitution 478C>T (Pro90Ser). A total of 219 patients with significant CAD and 236 control subjects were examined with regard to their genotypes, lipid profiles and other risk factors for CAD.

Results: The frequency of (TG) 11- or 12-repeat homozygotes was significantly higher in male CAD patients than in control men (28.4% vs. 15.7%, OR=2.13, p=0.018). Homozygosity for the (TG) 11- or 12-repeat allele was also significantly associated with a higher body mass index (BMI) compared to non-carriers in 134 control men after controlling for age, smoking and hypertension, and explains a 13% BMI variation observed in this study (p=0.015, analysis of covariance). For the 478C>T mutation, which has been reported to be associated with CD36 deficiency, there was no difference in the frequency of the 478T allele between CAD patients and control subjects. However, the 478T allele was found to be closely linked with a (TG) 11- or 12-repeat allele of intron 3 in the control subjects (χ2=18.88, p<0.001).

Conclusions: The (TG) repeat polymorphism in intron 3 of the CD36 gene is associated with a higher BMI and cardiovascular risk for men in a Korean population.

Clin Chem Lab Med 2007;45:1277–82.

Keywords: body mass index; CD36; coronary artery disease; obesity; polymorphisms

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